| Neutrophils Mean fluorescence*±SEM of stimulated cells (arbitrary units) | Healthy controls(HC) n=9 No treatments | Healthy controls n=6 post-Cotrimoxazole 7 days (960 mgBD) | Paired t test +significance at the 5% level (pre- and post Cotrimoxazole n=6) | IPF on long-term Cotrimoxazole (mean treatment duration 23 months, Cotrimoxazole (960 mgBD) n=8 | Mann Whitney U test HC versus IPF +significance at the 5% level |
|---|---|---|---|---|---|
| Mean neutrophil blood count 109/l (SEM) | 3.32±0.24 | 3.43±0.16 | 4.49±0.39 | ||
| PMA Nφ | 7014±1623 | 5903±1503 | p=0.683 | 3866±823 | p=0.117 |
| fMLP Nφ | 989±242 | 246±244 | p=0.015+ | 448±407 | p=0.08 |
| E coli Nφ | 4417±447 | 3302±815 | p=0.331 | 3606±358 | p=0.189 |
| Monocytes Mean fluorescence*±SEM of stimulated cells (arbitrary units) | Healthy controls (HC) No treatments n=9 | Healthy controls n=6 Cotrimoxazole 7 days (960 mgBD) | Paired t test +significance at the 5% level (pre- and post Cotrimoxazole n=6) | IPF on long-term Cotrimoxazole (mean treatment duration 23 months Cotrimoxazole (960 mgBD) n=8 | Mann Whitney U test HC versus IPF +significance at the 5% level |
| Mean monocyte blood count 109/l (SEM) | 0.55±0.06 | 0.53±0.08 | 0.77±0.07 | ||
| PMA Mφ | 503±149 | 236±109 | p=0.99 | 424±166 | p=0.541 |
| fMLP Mφ | 1467±460 | 38±24 | p=0.05+ | 1340±807 | p=0.276 |
| E coli Mφ | 990±168 | 787±136 | p=0.57 | 808±144 | p=0.733 |
*fluorescine agent dihydrorhodamine123-maximum absorption 488490 nm.