Abstract P275 Table 1

Summary of changes from baseline in lung function endpoints and rescue medication use, and trough FEV₁ responder analysis (ITT population)

	N	UMEC/VI	N	TIO/OLO	Difference/OR (95% CI) UMEC/VI vs TIO/OLO

Trough FEV₁, mL
Week 4	231	189 (13)	224	141 (13)	+48 (25, 71)^*
Week 8	225	180 (13)	224	128 (13)	+52 (28, 77)^*
Trough FEV₁ responders,^† n (%)
Week 4	234	162 (69)	227	116 (51)	OR: 2.09 (1.39, 3.14)^*
Week 8	234	154 (66)	229	109 (48)	OR: 2.05 (1.34, 3.14)^*
IC, mL
Week 4	223	164 (17)	215	112 (18)	+52 (16, 88)^**
Week 8	212	169 (17)	212	122 (17)	+47 (14, 81)^**
Rescue medication use (Weeks 1–8), puffs/day	222	−0.94 (0.08)	217	−0.68 (0.08)	−0.25 (-0.37,–0.14)^*

All data are presented as LS mean (SE) change from baseline, unless otherwise stated;
^*p<0.001; ^**p<0.01; ^† Defined as a change from baseline in trough FEV₁ of ≥100 mL
CI, confidence interval; FEV₁, forced expiratory volume in 1 s; IC, inspiratory capacity; ITT, intent-to-treat; LS, least squares; OR, odds ratio; SE, standard error; TIO/OLO, tiotropium/olodaterol 5/5 mcg; UMEC/VI, umeclidinium/vilanterol 62.5/25 mcg