Patient characteristics
| Pre Banding (2010 Annual Review Encounter) | Post Banding (2015 Annual Review Encounter) | |||
|---|---|---|---|---|
| Outcome | South of England/North of England (n=3017/3400) | South of England/North of England (n=3887/4120) | ||
| Summary statistics | p-value | Summary statistics | p-value | |
| Age: Mean±SD | 19.71±13.24/18.81±12.52 | 0.0052 | 20.82±14.23/20.3±13.78 | 0.0967 |
| Median | 18/18 | 19/19 | ||
| Gender, n(%) Female | 1423 (47.17)/1578 (46.41) | 1870 (48.11)/1894 (45.97) | ||
| Age at diagnosis, n(%) | ||||
| <3 months; n (%) | 1280 (42.43)/1590 (46.76) | 0.0052 | 1852 (47.65)/2121 (51.48) | <0.001 |
| ≥18 years; n (%) | 188 (6.23)/191 (5.62) | 0.2296 | 295 (7.59)/258 (6.26) | 0.0216 |
| FEV1 percent predicted | ||||
| (Overall) Mean±SD | 70.98±24.66/71.23±24.23 | 0.7172 | 73.5±24.53/72.24±24.84 | 0.041 |
| Age<16 Mean±SD | 84.51±17.99/81.57±19.80 | 0.0022 | 87.78±17.37/86.08±17.66 | 0.0361 |
| Age≥16 Mean±SD | 64.69±24.81/66.73±24.61 | 0.0153 | 67.6±24.63/66.6±25.13 | 0.1754 |
| Hypertonic Saline (n(%)) | 433 (14.35)/311 (9.15) | <0.001 | 1319 (33.93)/860 (20.87) | <0.001 |
| Dornase Alfa (n(%)) | 1394 (46.2)/1393 (40.97) | <0.001 | 2572 (66.17)/2274 (55.19) | <0.001 |
| Chronic macrolides (n(%)) | 1284 (42.56)/1445 (42.5) | 0.9822 | 1498 (38.54)/1607 (39.00) | 0.6856 |
| Asthma (n(%)) | 534 (17.7)/393 (11.56) | <0.001 | 685 (17.62)/538 (13.06) | <0.001 |
| CFRD (n(%)) | 528 (30.14)/623 (32.5) | 0.1325 | 838 (53.51)/957 (57.34) | 0.0389 |
| NTM (n(%)) | 116 (3.84)/55 (1.62) | <0.001 | 297 (7.64)/193 (4.68) | 0.001 |
| Pseudomonas (n(%)) | 1058 (35.07)/1359 (39.97) | <0.001 | 1100 (28.3)/1332 (32.33) | 0.0269 |