Efficacy of minocycline pleurodesis for primary spontaneous pneumothorax: medical and surgical
| Study author | Year | Study design | Total number of cases | Intervention (n) | Cointervention | Intervention recurrence rate (95% CI) | Control/reference arm (n)? | Control/reference recurrence rate (95% CI) | Follow-up period (months) | OR (vs control/reference) (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| RCT—medical | ||||||||||
| Chen52 | 2013 | RCT | 214 | Minocycline via chest drain (106) | Nil | 29.2% (19.2% to 44.4%) | Drainage only (108) | 49.1% (33.7% to 71.6%) | 19MN | 0.43 (0.24 to 0.75) |
| RCT—surgical | ||||||||||
| Chen51 | 2006 | RCT | 202 | Minocycline via chest drain (103)* | VATS+bullectomy | 1.9% (0.5% to 7.9%) | No agent (99) | 8.1% (3.9% to 16.6%) | 29MN | 0.23 (0.05 to 1.09) |
| Alayouty17 | 2011 | RCT | 82 | Minocycline via chest drain (42)* | VATS+bullectomy | 0% (0.0% to 7.1%) | Mechanical abrasion (40) | 5.0% (1.2% to 20.7%) | 36MN | 0.18 (0.01 to 3.89) |
| Retrospective case series—surgical | ||||||||||
| Chen53 | 2004 | Retrospective case series | 364 | Minocycline via chest drain (313)* | VATS+bullectomy | 2.9% (1.5% to 5.6%) | Saline (51)† | 9.8% (3.9% to 24.7%) | 48MN | 0.27 (0.09 to 0.85) |
| How54 | 2014 | Retrospective case series | 79‡ | Minocycline via chest drain (60) | VATS+bullectomy | 36.7% (21.7% to 62.0%) | OK-432 (19) | 5.3% (0.7% to 39.4%) | 16MN | 10.42 (1.30 to 83.50) |
*Minocycline introduced postsurgery once lung had re-expanded.
†Historical comparison.
‡Only patients with postoperative air leak after VATS were included.
RCT, randomised controlled trial; VATS, video-assisted thoracic surgery.