Efficacy of talc pleurodesis for primary spontaneous pneumothorax at thoracoscopy (no intervention on lung)
| Study author | Year | Study design | Total number of cases | Intervention (n) | Cointervention | Intervention recurrence rate (95% CI) | Control/reference arm (n)? | Control/reference recurrence rate (95% CI) | Follow-up period (months) | OR (vs control/reference) (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| RCT | ||||||||||
| Tschopp18 | 2002 | RCT | 108 | Talc poudrage (61) | Thoracoscopy only | 5.1% (1.6% to 16.2%) | Drainage only (47) | 34.0% (18.6% to 62.2%) | 61MN | 0.10 (0.03 to 0.38) |
| Retrospective case series (with comparator group) | ||||||||||
| Verschoof19 | 1988 | Retrospective case series | 61* | Talc poudrage (38) | Thoracoscopy only | 2.6% (0.4% to 19.2%) | Drainage only (23) | 26.1% (10.3% to 66.2%) | 48MN | 0.08 (0.01 to 0.69) |
| Retrospective case series (no comparator group) | ||||||||||
| Györik20 | 2007 | Retrospective case series | 59† | Talc poudrage (59) | Thoracoscopy‡ | 10.2%† (4.4% to 23.7%) | – | – | 118MD | – |
| Adewole21 | 2015 | Retrospective case series | 21* | Talc poudrage (21) | Thoracoscopy only | 9.5% (2.2% to 40.9%) | – | – | 24MN | – |
*Primary spontaneous pneumothorax patients only.
†Includes three early failures in recurrence rates.
‡Electrocoagulation performed in four cases.
MD, median; MN, mean; RCT, randomised controlled trial.