Lung cancer screening scan results: comparison of Queensland Lung Cancer Screening Study original definitions, Lung-RADS criteria, PanCan Model and differing nodule size thresholds
| Baseline round | Positive* | Negative | ||||
|---|---|---|---|---|---|---|
| d4 | 128 (50.0) | 128 (50.0) | ||||
| d6 | 64 (25.0) | CT scans n=256 (100.0) | 192 (75.0) | |||
| d8 | 32 (12.5) | 224 (87.5) | ||||
| Lung-RADS | 56 (21.9) | 200 (78.1) | ||||
| PanCan Model | 18 (7.0) | 238 (93.0) | ||||
| TP | FP | NA | TN | FN | NA | |
| d4 | 5 (2.0) | 123 (48.0) | 0 (0.0) | 127 (49.6) | 0 (0.0) | 1 (0.4) |
| d6 | 5 (2.0) | 59 (23.0) | 0 (0.0) | 191 (74.6) | 0 (0.0) | 1 (0.4) |
| d8 | 5 (2.0) | 27 (10.5) | 0 (0.0) | 223 (87.1) | 0 (0.0) | 1 (0.4) |
| Lung-RADS | 5 (2.0) | 51 (19.9) | 0 (0.0) | 199 (77.7) | 0 (0.0) | 1 (0.4) |
| PanCan Model | 5 (2.0) | 13 (5.1) | 0 (0.0) | 237 (92.6) | 0 (0.0) | 1 (0.4) |
| Incidence rounds | Positive | Negative | ||||
| d-All | 156 (33.1) | 316 (66.9) | ||||
| d4 | 44 (9.3) | CT scans n=472 (100.0) | 428 (90.7) | |||
| d6 | 26 (5.5) | 446 (94.5) | ||||
| d8 | 17 (3.6) | 455 (96.4) | ||||
| Lung-RADS | 46 (9.7) | 426 (90.3) | ||||
| TP | FP | NA | TN | FN | NA | |
| d-All | 7 (1.5) | 149 (31.6) | 0 (0.0) | 310 (65.7) | 0 (0.0) | 6 (1.3) |
| d4 | 7 (1.5) | 37 (7.8) | 0 (0.0) | 422 (89.4) | 0 (0.0) | 6 (1.3) |
| d6 | 5 (1.1) | 21 (4.4) | 0 (0.0) | 438 (92.8) | 2 (0.4) | 6 (1.3) |
| d8 | 5 (1.1) | 12 (2.5) | 0 (0.0) | 447 (94.7) | 2 (0.4) | 6 (1.3) |
| Lung-RADS | 6 (1.3) | 39 (8.3) | 1 (0.2) | 420 (89.0) | 1 (0.2) | 5 (1.1) |
Baseline (T0) and incidence (T1 and T2) screening rounds.
Data presented as count (%).
Criteria for positive baseline scan: d4 ≥4 mm threshold; d6 ≥6 mm threshold; d8 ≥8 mm threshold; Lung-RADS, Lung Imaging Reporting and Data System categories 3–4 and PanCan Model–Pan-Canadian multivariable logistic-regression risk model threshold ≥10%.
Criteria for positive incidence scan: d-All new or growing nodule(s) of any size; d4 ≥4 mm threshold; d6 ≥6 mm threshold; d8 ≥8 mm threshold and Lung-RADS categories 3–4.
*One baseline scan was positive due to non-nodule suspicious findings.
FN, false negative; FP, false positive; NA, not assessed; TN, true negative; TP, true positive.