TableĀ 3

Heritability estimates for lung cancer in the NorTwinCan cohort among those in the present analysis with smoking data, with and without adjustment for smoking status (n=1508 cases)

Case-wise concordance rates (95% CIs) Variance component estimates (95% CIs)
Number of complete MZ/DZ pairsMZDZAdjustment for smokingACE
5299/93590.22 (0.15 to 0.29)0.13 (0.09 to 0.17)No0.38 (0.05 to 0.72)0.06 (0.00 to 0.31)0.55 (0.43 to 0.68)
Yes0.34 (0.00 to 0.70)0.02 (0.00 to 0.29)0.64 (0.50 to 0.78)
  • All estimates adjusted for country and sex.

  • Variance components are: A: additive genetic effects, C: common environmental effects, and E: individually unique environmental effects estimated from biometrical twin model taking into account censoring (see methods in the online supplement).

  • DZ, dizygotic; MZ, monozygotic.