CLIPCOPD | COPDGene | ECLIPSE | ICECOLDERIC | LEUVEN | LifeLines | Lovelace | LHS | NJH | PAC-COPD | |
Italy, n=367 | USA, n=4471 | Europe and USA, n=2094 | Switzerland and The Netherlands, n=403 | Belgium, n=548 | The Netherlands, n=5198 | Southwestern USA, n=539 | USA, n=3132 | Colorado USA, n=60 | Spain, n=342 | |
Age (years) | 68.3 (8.9) | 57.1 (8.6) | 63.4 (7.1) | 67.3 (9.9) | 67.7 (8.6) | 53.2 (9.1) | 60.4 (8.8) | 49.3 (6.6) | 72.5 (10.0) | 67.9 (8.6) |
Sex: male, % | 80 | 56 | 66 | 57 | 76 | 48 | 34 | 64 | 53 | 93 |
Smoking: current, % | 35 | 43 | 36 | 38 | 43 | 28 | 56 | 100 | 7 | 35 |
FEV1 (% predicted) | 63.9 (24.0) | 57.4 (22.8) | 43.9 (15.0) | 55.4 (16.7) | 49.8 (18.7) | 90.8 (14.8) | 72.8 (18.9) | 76.8 (9.0) | 37.7 (15.1) | 52.3 (16.2) |
FEV1/FVC (%) | 53.5 (11.4) | 52.2 (13.4) | 44.6 (11.5) | 51.8 (11.8) | 45.2 (12.0) | 64.7 (5.6) | 59.8 (9.3) | 63.1 (5.3) | 54.1 (10.0) | 53.4 (12.0) |
FVC (%predicted) | 93.8 (24.7) | 81.9 (20.4) | 79.6 (19.9) | 87.3 (19.6) | 45.2 (12.0) | 115.7 (15.8) | 92.7 (17.4) | 95.7 (10.4) | 65.2 (19.3) | 72.6 (16.4) |
BMI (kg/m2) | 26.3 (4.7) | 27.9 (6.1) | 26.5 (5.6) | 26.1 (5.2) | 24.9 (5.2) | 25.9 (3.7) | 26.8 (5.9) | 25.5 (3.8) | 27.4 (8.3) | 28.2 (4.7) |
MMRC (0–4) | 2.1 (1.0) | 1.9 (1.5) | 1.7 (1.1) | 1.9 (1.5) | 1.9 (1.1) | 0.3 (0.7) | 1.3 (1.2) | 0.5 (0.7) | 2.9 (0.9) | 1.7 (1.2) |
Asthma, % | 1 | 23 | 22 | 4 | 0 | 13 | 25 | 8 | 7 | 67 |
CVD, % | 45 | 20 | 22 | 20 | 38 | 5 | 28 | 1 | 23 | 25 |
Values are mean (SD) unless otherwise noted.
BMI. body mass index; CVD, cardiovascular disease; MMRC, Modified Medical Research Council.