Pairwise correlations in liability, heritability estimates and model fit parameters for liability to incident lung cancer among ever smoking and current smoking concordant twin pairs from the NorTwinCan study
| Correlation (95% CI) | A | C | E | ||||
|---|---|---|---|---|---|---|---|
| Model | MZ | DZ | Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | AIC | p Value |
| Ever smokers | |||||||
| ACE | 0.35 (0.21 to 0.49) | 0.21 (0.09 to 0.33) | 0.28 (0.0 to 0.66) | 0.07 (0.0 to 0.36) | 0.65 (0.50 to 0.79) | 38759.12 | 0.01* |
| AE | 0.37 (0.25 to 0.49) | 0† | 0.63 (0.51 to 0.75) | 38757.92 | 0.35 | ||
| CE | 0† | 0.28 (0.19 to 0.37) | 0.72 (0.63 to 0.81) | 38764.19 | 0 | ||
| Current smokers | |||||||
| ACE | 0.39 (0.20 to 0.55) | 0.24 (0.10 to 0.38) | 0.29 (0.0 to 0.74) | 0.10 (0.0 to 0.44) | 0.62 (0.44 to 0.79) | 30484.27 | 0.12* |
| AE | 0.41 (0.26 to 0.56) | 0† | 0.59 (0.44 to 0.74) | 30483.46 | 0.27 | ||
| CE | 0† | 0.31 (0.20 to 0.42) | 0.69 (0.58 to 0.80) | 30488.49 | 0.01 | ||
*Compared to the saturated model; the other models are compared to the ACE model.
†95% CI for C effect here could not be estimated reliably.
Estimates of genetic (A), shared environmental (C) and unshared environmental (E) variance are presented for the ACE, AE and CE models.
AIC, Akaike information criterion’ DZ, dizygotic; MZ, monozygotic.