Cox proportional hazards models for CLAD-free survival as a function of donor and recipient telomere length
| HR | 95% CI | p Value | |
|---|---|---|---|
| Multivariable risk of CLAD or death model*† | |||
| Telomere length (per 1 kb decrease) | |||
| Donor | 1.25 | 1.03 to 1.52 | 0.02 |
| Recipient | 1.02 | 0.87 to 1.2 | 0.79 |
| Age (per decade) | |||
| Donor | 1.03 | 0.86 to 1.22 | 0.76 |
| Recipient | 1.06 | 0.8 to 1.41 | 0.67 |
| Multivariable risk of CLAD or death interaction model* | |||
| Telomere length (per 1 kb decrease) | |||
| Donor | 2.39 | 1.4 to 4.07 | 0.001 |
| Age (per decade) | |||
| Donor | 0.29 | 0.11 to 0.79 | 0.02 |
| Donor age* donor telomere length | |||
| Interaction | 0.83 | 0.71 to 0.96 | 0.01 |
| Donor age stratified, multivariable-adjusted risk of CLAD or death models* | |||
| Donor telomere length (per 1 kb decrease) | |||
| Donor age <30 | 1.65 | 1.18 to 2.31 | 0.004 |
| Donor age ≥30 | 1 | 0.79 to 1.27 | 0.97 |
*Includes donor and recipient telomere length, age, diagnosis group, lung allocation score, donor gender, recipient gender, non-Hispanic white donor, non-Hispanic white recipient, transplant type and donor ‘ever smoker’ status.
†Univariable and multivariable models including all covariates are included as online supplementary table S3.
CLAD, chronic lung allograft dysfunction.