The effect of high-dose versus low-dose aspirin on bronchoalveolar lavage (BAL) and plasma biomarkers
| Aspirin 75 mg | Aspirin 1200 mg | |
|---|---|---|
| BAL | ||
| Neutrophils (×105/mL) | 1.6 (1.3–2.8) | 1.5 (1.2–1.7) |
| MMP-8 (ng/mL) | 3.4 (2.3–4.8) | 2.6 (1.9–4.0) |
| MMP-9 (ng/mL) | 33.7 (27.1–50.1) | 33.7 (16.1–44.4) |
| MPO (ng/mL) | 38.6 (29.2–53.3) | 25.2 (17.5–34.6) |
| NE (ng/mL) | 10.6 (6.0–15.6) | 21.1 (11.1–36.1) |
| TNFα (pg/mL) | 77 (51–100) | 90 (49–141) |
| IL-6 (pg/mL) | 563 (368–880) | 782 (284–901) |
| IL-8 (pg/mL) | 308 (264–431) | 397 (269–515) |
| MCP-1 (pg/mL) | 497 (385–967) | 502 (289–924) |
| IL-1β (pg/mL) | 46 (30–66) | 30 (16–38) |
| IL-1Ra (pg/mL) | 3000 (2413–4182) | 2266 (1700–3682) |
| TIMP-1 (pg/mL) | 2155 (1431–3783) | 2243 (1275–3789) |
| TIMP-2 (pg/mL) | 566 (495–912) | 574 (224–805) |
| SP-D (pg/mL) | 27810 (23 356–38 705) | 35242 (23 800–41 848) |
| CRP (pg/mL) | 449 (97–943) | 237 (116–867) |
| Plasma | ||
| CRP (mg/L) | 40 (33–61) | 32 (25–63) |
Data are median (IQR).
IL, interleukin; TNFα, tumour necrosis factor α.