Table 3

The effect of aspirin on bronchoalveolar lavage (BAL) cytokines in healthy volunteers who inhaled lipopolysaccharide

BAL analytePlaceboAspirinDifference in median (95% CI)p Value
TNFα (pg/mL)106 (87–154)78 (52–128)33 (1.91 to 63.74)0.03
IL-1β (pg/mL)43 (26–99)37 (19–55)13 (−6 to 46)0.17
IL-1β:IL-1Ra0.02 (0.01–0.03)0.01 (0.008–0.014)0.01 (−.0.001 to 0.02)0.07
IL-6 (pg/mL)857 (606–1263)648 (330–835)258 (−40 to 526)0.07
IL-8 (pg/mL)448 (321–657)346 (275–508)102 (−40 to 253)0.11
MCP-1 (pg/mL)547 (412–1055)502 (348–888)83 (−168 to 363)0.45
CRP (pg/mL)332 (93–1140)308 (114–824)9 (−351 to 266)0.99
  • IL, interleukin; TNFα, tumour necrosis factor α; MCP, Monocyte chemoattractant protein.