Table 4

Multivariable associations of 6-month physical measures with 6-month patient-centred outcomes

6-month physical measuresAlive at home†
at 6 months
OR (95% CI)
SF-36 PCS
at 6 months
β (95% CI)
EQ-5D utility
at 6 months
β (95% CI)
ICAPALTOSICAPALTOSICAPALTOS
N=95N=133N=99N=134N=99N=133
Body structure and function
 FEV1, each 10% predicted1.46 (0.53 to 4.02)0.88 (0.55 to 1.39)0.00 (−1.12 to 1.12)0.76 (−0.14 to 1.65)−1.09 (−2.98 to 0.79)0.60 (−1.07 to 2.27)
 % muscle area, each 10%1.91 (0.58 to 6.24)0.94 (0.61 to 1.45)2.21 (0.57 to 3.85)**−0.39 (−1.32 to 0.54)1.80 (−0.97 to 4.56)−0.31 (−2.04 to 1.42)
 MIP, each 10% predicted0.90 (0.54 to 1.50)0.99 (0.76 to 1.30)0.19 (−0.45 to 0.83)0.31 (−0.25 to 0.87)0.37 (−0.70 to 1.44)0.45 (−0.59 to 1.49)
 MMT, each 10% max MRC score1.12 (0.18 to 7.06)0.89 (0.27 to 2.91)0.56 (−1.94 to 3.06)2.19 (−0.36 to 4.73)−0.57 (−4.78 to 3.65)1.57 (−3.23 to 6.36)
 Grip strength, each 10% predicted0.76 (0.39 to 1.49)0.97 (0.67 to 1.40)−0.32 (−1.24 to 0.59)−0.34 (−1.02 to 0.34)−0.94 (−2.48 to 0.60)−0.67 (−1.94 to 0.60)
Activity
 6 min walk, each 10% predicted1.86 (0.80 to 4.32)1.32 (0.83 to 2.09)1.52 (0.37 to 2.66)*0.99 (0.03 to 1.94)*2.77 (0.84 to 4.70)**0.59 (−1.20 to 2.37)
 4 m gait speed (per 0.11 m/s)‡0.94 (0.69 to 1.29)0.55 (−0.13 to 1.23)1.17 (−0.09 to 2.44)
Participation
 No. ADL dependencies (ICAP only)0.49 (0.12 to 1.99)0.63 (−1.86 to 3.12)−0.14 (−4.34 to 4.05)
 No. IADL dependencies (ICAP only)0.91 (0.46 to 1.80)−1.88 (−2.94 to −0.82)**−2.50 (−4.28 to −0.72)**
 FPI––total, per 0.20 unit§ (ALTOS only)1.17 (0.87 to 1.56)1.52 (0.89 to 2.15)**3.67 (2.50 to 4.84)**
Model fit; variance explainedAUC=0.88AUC=0.75R2=0.29R2=0.43R2=0.17R2=0.41
  • ‘–’, measure not available in dataset.

  • *p≤0.05; **p≤0.01.

  • †Alive at home outcome for 6 months (yes=1, no=0; ICAP––1, n=92, 97%, 0, n=3, 3%; ALTOS––1, n=125, 94%; 0, n=8, 6%).

  • ‡0.11 m/s is an estimated MCID for the 4 m gait speed test based on prior study among patients with COPD.31

  • §0.20 is an estimated MCID for the FPI. There was no evidence of multicollinearity (variance inflation factor ≤1.59 for independent variables estimated within each model).

  • ADL, activities of daily living; ALTOS, ARDSNet Long-Term Outcome Study; AUC, area under the curve; EQ-5D, Euro-QOL; FPI, Functional Performance Inventory; IADL, instrumental activities of daily living; ICAP, Improving Care of Acute Lung Injury Patients; MCID, minimal clinically important difference; MIP, maximal inspiratory pressure; MMT, manual muscle testing; MRC, Medical Research Council; QOL, Quality of Life; SF-36 PCS, Medical Outcomes Study Short-Form 36 physical component score.