Clinical characteristics of patients included in the clusters resembling the ‘severe airflow limitation, low BMI and poor health status’ subtype
| Cohort | CLIPCOPD | COPDGene | ECLIPSE | ICECOLDERIC | LEUVEN | PAC-COPD |
| n (% of the cohort) | 144 (39%) | 880 (20%) | 250 (12%) | 51 (13%) | 95 (17%) | 58 (17%) |
| FEV1 (%predicted) | 41.8 (11.6) | 26.8 (7.4) | 24.8 (4.7) | 27.9 (6.7) | 29.6 (6.4) | 32 (8.0) |
| FEV1/FVC (%) | 47.7 (11.2) | 34.9 (7.6) | 30.3 (4.2) | 38.2 (10.3) | 37.5 (7.4) | 41.1 (8.0) |
| FVC (%predicted) | 71.4 (15.8) | 58.8 (12.3) | 63.7 (11.9) | 63.0 (14.9) | 63.2 (9.9) | 57.9 (9.3) |
| BMI (kg/m2) | 25.4 (4.3) | 26.2 (5.7) | 23.9 (4.1) | 23.5 (3.2) | 23.7 (5.3) | 24.9 (3.5) |
| MMRC (0–4) | 2.3 (1.0) | 3.2 (0.7) | 2.5 (0.8) | 2.5 (1.3) | 2.4 (1.1) | 1.9 (1.3) |
| Asthma, % | 1 | 27 | 26 | 2 | 0 | 79 |
| CVD, % | 36 | 23 | 20 | 14 | 37 | 7 |
Values are mean (SD) unless otherwise noted. Complete description of best NMI cluster solutions for each cohort are available in online supplementary tables 2–11.
BMI. body mass index; CVD, cardiovascular disease; MMRC, Modified Medical Research Council; NMI, normalised mutual information.