Table 2

Ambulatory blood pressure results before and after treatment with morning and evening dosing of perindopril*

VariableBaselineAM dosingChange from baseline to AM dosing
(95% CI)
p Value for changePM dosingChange from baseline to PM dosing
(95% CI)
p Value for changeDifference between groups†
(95% CI)
p Value for difference between groups†
Wake mean SBP, mm Hg147.8±1.1137.9±1.1−9.8 (−10.5 to −9.1)<0.001139.7±1.1−8.0 (−8.7 to −7.3)<0.0011.8 (1.1 to 2.5)<0.001
Sleep mean SBP, mm Hg126.7±1.4118.7±1.4−8.0 (−9.4 to −6.6)<0.001119.8±1.4−6.9 (−8.3 to −5.5)<0.0011.1 (−0.3 to 2.5)0.14
24-Hour mean SBP, mm Hg143.6±1.1134.0±1.1−9.6 (−10.3 to −8.8)<0.001135.6±1.1−8.0 (−8.7 to −7.2)<0.0011.6 (0.8 to 2.3)<0.001
Wake mean DBP, mm Hg90.8±0.985.6±0.9−5.2 (−5.7 to −4.7)<0.00186.7±0.9−4.2 (−4.7 to −3.6)<0.0011.1 (0.5 to 1.6)<0.001
Sleep mean DBP, mm Hg76.1±0.971.7±0.9−4.3 (−5.4 to −3.3)<0.00172.0±0.9−4.1 (−5.1 to −3.0)<0.0010.3 (−0.8 to 1.3)0.60
24-Hour mean DBP, mm Hg87.9±0.882.8±0.8−5.1 (−5.6 to −4.6)<0.00183.6±0.8−4.3 (−4.8 to −3.7)<0.0010.8 (0.3 to 1.4)0.003
  • *Values are mean±SE.

  • †Refers to ‘change from baseline to PM dosing’–‘change from baseline to AM dosing’.

  • AM, morning dosing; DBP, diastolic blood pressure; PM, evening dosing; SBP, systolic blood pressure.