Table 3

Ambulatory blood pressure results before and after addition of CPAP to either morning or evening dosing of perindopril*

VariableAM dosingAM dosing and CPAPChange from AM dose to AM and CPAP
(95% CI)
p Value for changePM dosingPM dosing and CPAPChange from PM dose to PM and CPAP
(95% CI)
p Value for changeDifference between groups†
(95% CI)
p Value for difference between groups†
Wake mean SBP, mm Hg137.3±1.7138.1±1.70.8 (−0.1 to 1.8)0.10137.8±1.8139.0±1.81.2 (0.1 to 2.2)0.030.8 (−4.1 to 5.8)0.74
Sleep mean SBP, mm Hg119.5±1.9116.1±1.9−3.3 (−5.2 to −1.5)<0.001121.2±2.0118.0±2.0−3.2 (−5.1 to −1.3)<0.0011.9 (−3.6 to 7.4)0.49
24-Hour mean SBP, mm Hg133.8±1.7134.2±1.70.4 (−0.6 to 1.5)0.40134.2±1.7134.7±1.70.5 (−0.6 to 1.5)0.390.5 (−4.3 to 5.2)0.85
Wake mean DBP, mm Hg84.9±1.383.9±1.3−1.0 (−1.7 to −0.4)0.00385.8±1.485.4±1.4−0.5 (−1.2 to 0.3)0.211.5 (−2.4 to 5.3)0.45
Sleep mean DBP, mm Hg72.4±1.469.2±1.4−3.2 (−4.6 to −1.8)<0.00172.7±1.471.5±1.4−1.2 (−2.7 to 0.2)0.102.3 (−1.7 to 6.3)0.25
24-Hour mean DBP, mm Hg82.5±1.381.3±1.3−1.2 (−1.9 to −0.5)<0.00182.9±1.382.4±1.3−0.5 (−1.2 to 0.3)0.221.2 (−2.5 to 4.8)0.53
  • *Values are mean±SE.

  • †Refers to ‘PM dosing and CPAP’–‘AM dosing and CPAP’.

  • AM, morning dosing; DBP, diastolic blood pressure; PM, evening dosing; SBP, systolic blood pressure.