Variants selected for follow-up and their association with longitudinal change in lung function (FEV1, FVC and FEV1/FVC) in Busselton Health Study (BHS)
| Variant | Top variant in region | Chr | Position | Risk allele | Other allele | Risk allele frequency | β | SE | p Value |
|---|---|---|---|---|---|---|---|---|---|
| (a) FEV1 (mL/year) | |||||||||
| rs114969412 | rs114969412 | 1 | 106234189 | G | A | 0.06 | −4.84 | 1.00 | 1.29×10−6 |
| rs13099788 | rs13099788 | 3 | 192286178 | C | G | 0.56 | −2.29 | 0.488 | 2.75×10−6 |
| rs3819182 | rs3819182 | 4 | 101107664 | A | C | 0.40 | −2.14 | 0.460 | 3.47×10−6 |
| rs3113685 | rs3113685 | 4 | 109982140 | G | T | 0.39 | −2.71 | 0.571 | 1.98×10−6 |
| rs876365 | rs3113685 | 4 | 109989467 | C | T | 0.31 | −2.19 | 0.483 | 5.65×10−6 |
| 5:51298598:T_TG | 5:51298598:T_TG | 5 | 51298598 | I | R | 0.05 | −6.19 | 1.32 | 2.97×10−6 |
| rs76575180 | 5:51298598:T_TG | 5 | 51546441 | G | T | 0.03 | −6.72 | 1.61 | 3.15×10−5 |
| 5:136298545:A_AG | 5:136298545:A_AG | 5 | 136298545 | I | R | 0.88 | −3.16 | 0.691 | 4.91×10−6 |
| rs72901148 | rs72901148 | 6 | 79562115 | A | G | 0.02 | −8.95 | 1.73 | 2.15×10−7 |
| rs11158759 | rs11158759 | 14 | 69162043 | C | T | 0.84 | −2.87 | 0.627 | 4.73×10−6 |
| rs6502247 | rs6502247 | 17 | 13203562 | G | A | 0.87 | −3.93 | 0.663 | 3.23×10−9 |
| rs8073053 | rs8073053 | 17 | 19553382 | A | G | 0.30 | −2.38 | 0.518 | 4.41×10−6 |
| rs8132156 | rs8132156 | 21 | 47062729 | A | G | 0.10 | −4.17 | 0.833 | 5.72×10−7 |
| rs113301658 | rs113301658 | 22 | 34148991 | C | G | 0.14 | −4.57 | 0.826 | 3.21×10−8 |
| (b) FVC (mL/year) | |||||||||
| 1:44578970:G_GCA | 1:44578970:G_GCA | 1 | 44578970 | R | I | 0.98 | −10.3 | 2.10 | 1.07×10−6 |
| rs878118 | rs878118 | 3 | 71246228 | T | G | 0.80 | −3.39 | 0.727 | 3.11×10−6 |
| rs150801948 | rs150801948 | 6 | 15920550 | T | C | 0.02 | −10.0 | 2.16 | 3.46×10−6 |
| rs111605394 | rs111605394 | 7 | 51412802 | A | T | 0.96 | −9.11 | 1.78 | 2.91×10−7 |
| 8:105858623:TTTC_ | 8:105858623:TTTC_ | 8 | 105858623 | R | D | 0.19 | −3.84 | 0.818 | 2.71×10−6 |
| 9:424077:TA_T | 9:424077:TA_T | 9 | 424077 | D | R | 0.01 | −14.8 | 3.09 | 1.70×10−6 |
| rs118036814 | rs118036814 | 11 | 107316060 | A | G | 0.07 | −6.43 | 1.26 | 3.59×10−7 |
| 13:94098659:CT_C | 13:94098659:CT_C | 13 | 94098659 | D | R | 0.24 | −3.32 | 0.701 | 2.18×10−6 |
| rs62028012 | rs62028012 | 15 | 97946036 | C | T | 0.73 | −3.55 | 0.751 | 2.26×10−6 |
| rs1862844 | rs6539968 | 16 | 86758079 | C | A | 0.61 | −4.64 | 0.878 | 1.24×10−7 |
| rs6539968 | rs6539968 | 16 | 86759924 | C | T | 0.64 | −2.90 | 0.614 | 2.30×10−6 |
| 18:39303165:GTAGA | 18:39303165:GTAGA | 18 | 39303165 | R | D | 0.92 | −5.21 | 1.13 | 4.35×10−6 |
| rs12965811 | rs12965811 | 18 | 63173334 | T | G | 0.07 | −5.78 | 1.19 | 1.16×10−6 |
| rs113179796 | rs10404081 | 19 | 22748391 | C | T | 0.95 | −12.0 | 2.21 | 5.17×10−8 |
| rs10404081 | rs10404081 | 19 | 22756773 | A | G | 0.97 | −8.97 | 1.95 | 4.25×10−6 |
| rs10404632 | rs10404081 | 19 | 22763493 | T | C | 0.96 | −6.23 | 1.49 | 2.89×10−5 |
| rs2740192 | rs2740185 | 20 | 3059396 | C | T | 0.14 | −4.33 | 0.976 | 8.98×10−6 |
| rs2740185 | rs2740185 | 20 | 3061436 | A | G | 0.20 | −4.35 | 0.930 | 3.00×10−6 |
| (c) FEV1/FVC (change per year) | |||||||||
| rs11694877 | rs11694877 | 2 | 5992517 | G | T | 0.91 | −6.43×10−4 | 1.39×10−4 | 3.79×10−6 |
| rs72847294 | rs72847294 | 2 | 88684174 | G | A | 0.07 | −7.90×10−4 | 1.52×10−4 | 2.14×10−7 |
| rs6434439 | rs6434439 | 2 | 191997584 | A | C | 0.43 | −3.86×10−4 | 8.43×10−5 | 4.57×10−6 |
| rs73832306 | rs73832306 | 4 | 99370515 | T | C | 0.97 | −1.13×10−3 | 2.48×10−4 | 4.90×10−6 |
| rs10043201 | rs116563943 | 5 | 1600242 | G | A | 0.77 | −4.57×10−4 | 1.01×10−4 | 6.03×10−6 |
| rs116563943 | rs116563943 | 5 | 1606844 | G | T | 0.82 | −6.74×10−4 | 1.45×10−4 | 3.26×10−6 |
| rs58140608 | rs114704427 | 5 | 170929096 | C | T | 0.93 | −7.19×10−4 | 1.66×10−4 | 1.43×10−5 |
| rs114704427 | rs114704427 | 5 | 170941277 | C | T | 0.98 | −1.83×10−3 | 3.54×10−4 | 2.18×10−7 |
| rs512976 | rs512976 | 6 | 7163873 | T | C | 0.15 | 5.29×10−4 | 1.14×10−4 | 3.20×10−6 |
| rs11136718 | rs11136718 | 8 | 4157216 | G | A | 0.63 | −4.22×10−4 | 9.19×10−5 | 4.27×10−6 |
| rs4737863 | rs4737863 | 8 | 68857698 | G | C | 0.45 | −3.71×10−4 | 7.89×10−5 | 2.56×10−6 |
| rs72671203 | rs72671203 | 14 | 20673455 | G | A | 0.13 | −5.72×10−4 | 1.18×10−4 | 1.20×10−6 |
| rs17197324 | rs17197324 | 14 | 22079359 | C | G | 0.83 | −4.94×10−4 | 1.03×10−4 | 1.80×10−6 |
| rs117466318 | rs117466318 | 14 | 82200378 | A | G | 0.97 | −1.17×10−3 | 2.56×10−4 | 4.60×10−6 |
| rs80245972 | rs117466318 | 14 | 82205915 | C | T | 0.92 | −5.80×10−4 | 1.43×10−4 | 4.72×10−5 |
| rs16960347 | rs16960347 | 17 | 64889056 | C | T | 0.93 | −7.21×10−4 | 1.58×10−4 | 4.83×10−6 |
Betas provided correspond to the risk allele. Risk allele here is defined as the allele associated with decreased lung function in BHS.
Variants are given in order of Chr and position.
β, per-allele change in FEV1, FVC or FEV1/FVC; Chr, chromosome.