Table 2

Test characteristics of HRCT possible UIP pattern, alone and with consideration of other clinical and radiographic features, for definite/probable histopathological UIP

PatternSensitivitySpecificityPPVNPVAUROCLR+
Possible UIP-UCSF35.4 (26.6–45.0)91.2 (87.2–94.3)62.5 (49.5–74.3)77.3 (72.3–81.7)0.63 (0.58–0.68)4.01 (2.54–6.33)
Possible UIP-Mayo60.4 (50.6–69.5)92.7 (82.4–98.0)94.4 (86.2–98.4)53.7 (43.2–64.0)0.77 (0.71–0.82)8.30 (3.19–21.58)
Possible UIP with traction bronchiectasis score ≥4* and male ≥60-UCSF16.8 (10.4–25.0)99.6 (98.0–100)95.0 (75.1–99.9)74.2 (69.4–78.7)0.58 (0.55–0.62)45.7 (6.2–338)
Possible UIP with traction bronchiectasis score ≥4* and male ≥60-Mayo32.4 (23.9–42.0)98.2 (90.3–100.0)97.3 (85.8–99.9)41.9 (33.2–50.9)0.65 (0.61–0.70)17.84 (2.51–126.70)
Inconsistent with UIP-UCSF64.6 (55.0–73.48.8 (5.7–12.8)22.7 (18.3–27.7)37.5 (25.7–50.5)0.37 (0.32–0.41)0.71 (0.61–0.82)
Inconsistent with UIP-Mayo39.6 (30.5–49.4)7.3 (2.0–17.6)46.3 (36.0–56.8)5.6 (1.6–13.8)0.23 (0.18–0.29)0.43 (0.34–0.54)
  • *The extent of radiographic traction bronchiectasis was scored in each lobe (right upper, middle, and lower lobes and left upper, lingula, and lower lobes) as 0-absent, 1-mild, 2-moderate, or 3-severe, and then summed to provide a total traction bronchiectasis score (see online supplementary figure S1 and ref. 14).

  • AUROC, area under the receiver-operator curve; HRCT, high-resolution CT; LR+, positive likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; UCSF, University of California, San Francisco; UIP, usual interstitial pneumonia.