Associations of cholesterol and lipoproteins with MMP-7 and SP-A
| % change in MMP-7 (95% CI)* | p Value | % change in SP-A (95% CI)* | p Value | |
|---|---|---|---|---|
| Total cholesterol | −0.01 (−2.25 to 2.28) | 0.99 | 1.43 (−2.95 to 6.00) | 0.52 |
| HDL-C, mg/dL | −3.53 (−6.07 to −0.93) | 0.008 | −6.37 (−11.13 to −1.35) | 0.01 |
| LDL-C, mg/dL | 0.35 (−2.55 to 1.89) | 0.76 | 3.44 (−0.98 to 8.05) | 0.13 |
| Triglycerides | 2.81 (0.30 to 5.37) | 0.03 | −3.11 (−7.69 to 1.70) | 0.20 |
| Large HDL, 9.4–14 nm | −4.10 (−7.26 to −0.84) | 0.01 | −14.39 (−19.82 to −8.59) | <0.001 |
| Medium HDL, 8.2–9.4 nm | −4.92 (−7.61 to −2.14) | <0.001 | −1.67 (−7.06 to 4.02) | 0.56 |
| Small HDL, 7.3–8.2 nm | −5.32 (−8.03 to −2.53) | <0.001 | −8.23 (−13.31 to −2.86) | 0.003 |
| Large LDL, 20.5–23 nm | −4.86 (−7.50 to −2.15) | <0.001 | −0.68 (−6.02 to 4.96) | 0.81 |
| Small LDL, 18–20.5 nm | −1.51 (−4.73 to 1.81) | 0.37 | −7.35 (−13.18 to −1.12) | 0.02 |
| Apolipoprotein A-1 | −2.83 (−5.32 to −0.27) | 0.03 | −4.79 (−9.56 to 0.12) | 0.06 |
| Apolipoprotein B | 1.74 (−0.64 to 4.18) | 0.15 | 1.51 (−3.06 to 6.36) | 0.52 |
Solid lines separate distinct models. Each model includes all exposure variables listed and is additionally adjusted for age, gender, race/ethnicity, body mass index, smoking status, cigarette pack-years, presence of coronary artery calcium, statin use, interleukin 6 and C reactive protein.
*Reported per SD in each exposure variable.