Table 3

Cumulative effect of total number of oPEx events during the study period and lung function decline

 Model 1 slopeModel 2 slope
Coefficient (95% CI)Coefficient (95% CI)
FEV1% predicted decline with age 0–3 oPEx events*−1.04 (−1.15 to −0.92)−0.31 (−0.40 to −0.23)
FEV1% predicted decline with age 4–6 oPEx events*−1.09 (−1.21 to −0.97)−0.40 (−0.51 to −0.29)
FEV1% predicted decline with age >6 oPEx events*−1.24 (−1.38 to −1.11)−0.75 (−0.87 to −0.62)
  • The relationship between each predictor and FEV1 is presented as the slopes of association (95% CI).

  • *Estimated by fitting stratified models for each tertile (0–3, 3–6, 6+) of the cumulative number of oPEx events during the study period. Negative coefficients represent decreasing FEV1 and positive coefficients represent increasing FEV1.

  • Model 1: included age and time in study.

  • Model 2: included age and time in study as well cumulative number of iPEx events, age group (paediatric vs adult), gender, age at diagnosis, pancreatic status, CFRD, baseline FEV1% predicted and infection with H. influenzae, Aspergillus species and A. xylosoxidans.

  • Significant results are bold if p<0.05.

  • CFRD, cystic fibrosis-related diabetes.