Table 2

The association between oPEx events in the previous 12 months and FEV1% predicted

 Model 1Model 2Model 3
Coefficient (95% CI)Coefficient (95% CI)Coefficient (95% CI)
oPEx event in the previous 12 months
 0RefRefRef
 1−0.37 (−0.71 to −0.04)−0.34 (−0.67 to −0.003)−0.30 (−0.64 to 0.03)
 ≥2−0.52 (−0.89 to −0.15)−0.48 (−0.86 to −0.11)−0.33 (−0.71 to 0.04)
iPEx event in the previous 24 months
 0RefRefRef
 1−0.63 (−1.06 to −0.19)−0.56 (−0.99 to −0.13)−0.47 (−0.91 to −0.04)
 ≥2−0.22 (−0.79 to 0.35)−0.14 (−0.71 to 0.44)−0.04 (−0.61 to 0.54)
Increasing age×centred at 23 years−1.05 (−1.19 to −0.90)−1.03 (−1.17 to −0.88)−0.95 (−1.09 to 0.80)
  • The relationship between each predictor and FEV1 is presented as the slopes of association (95% CI).

  • Model 1: included age (centred at 23 years) and follow-up time and either oPEx or iPEx events (treated as time-varying variables).

  • Model 2: included age (centred at 23 years) and follow-up time, oPEx events in the past 12 months and iPEx events in the past 24 months both treated as time-varying variables.

  • Model 3: included age (centred at 23 years), follow-up time as well as all time-varying factors that were significant at the p<0.15 level (CFRD, Aspergillus infection, MRSA infection).

  • Negative coefficients represent decreasing FEV1 and positive coefficients represent increasing FEV1.

  • Significant results are bold if p<0.05.

  • CFRD, cystic fibrosis-related diabetes; MRSA, methicillin-resistant Staphylococcus aureus.