Table 4

Risk factors for treatment failure or death

Favourable outcome N=512*Poor outcome N=15†Unadjusted OR (95% CI), p valueAdjusted OR (95% CI), p value
Age over 60 years133/512 (26.0)8/15 (53.3)3.26 (1.16 to 9.15), 0.0333.18 (0.84 to 12.03), 0.088
BMI
 BMI<18.5121/512 (23.6)4/15 (26.7)1
 18.5≤BMI<25338/512 (66.0)9/15 (60.0)0.77 (0.27 to 2.21), 0.772
 BMI≥2553/512 (10.4)2/15 (13.3)1.33 (0.29 to 6.07), 0.711
Smoking status
 Non-smoker495/512 (96.7)2/15 (13.3)11
 Past smoker70/512 (13.7)5/15 (33.3)3.16 (1.05 to 9.51), 0.0414.79 (0.84 to 12.03), 0.078
 Current smoker139/512 (27.1)8/15 (53.3)3.07 (1.09 to 8.62), 0.0336.23 (1.16 to 33.50), 0.033
Symptom score ≥479/512 (15.4)5/15 (33.3)2.74 (0.91 to 8.23), 0.0741.82 (0.42 to 7.85), 0.421
Status of DM
 Non-DM4.3/512 (78.7)5/15 (33.3)11
 Controlled-DM35/512 (6.8)1/15 (6.7)2.30 (0.26 to 20.26), 0.4520.97 (0.10 to 9.59), 0.978
 Uncontrolled-DM74/512 (14.5)9/15 (60)9.80 (0.32 to 30.07), <0.0014.11 (1.23 to 13.78), 0.022
Positive smear224/512 (43.8)11/15 (73.3)3.54 (1.11 to 11.25), 0.0231.21 (0.30 to 4.99), 0.788
Drug resistant (any drug)46/510 (9.0)2/14 (14.3)1.68 (0.37 to 7.74), 0.373
Cavity194/512 (37.9)8/15 (53.3)1.87 (0.67 to 5.25), 0.225
Multi-lobe involvement‡139/512 (27.1)11/15 (73.3)7.38 (2.31 to 23.56), <0.0013.73 (1.02 to 13.71), 0.047
Consolidation301/512 (58.8)11/15 (73.3)1.93 (0.61 to 6.14), 0.259
Comorbidity§70/512 (13.7)6/15 (40.0)4.21 (1.45 to 12.19), 0.0132.09 (0.55 to 7.99), 0.283
Compliance <95%22/512 (4.3)1/12 (8.3)2.02 (0.25 to 16.39), 0.420
  • Data are presented as the number (%) of subjects, unless otherwise indicated.

  • *Favourable outcomes include cure or treatment completion.

  • †Poor outcomes include treatment failure or death.

  • ‡Multi-lobe involvement indicates lung involvement of more than three lobes.

  • §Comorbidities include end-stage renal disease, heart disease and cancer.

  • BMI, body mass index (kg/m2).