Summary of baseline demographics: baseline statin users and non-users
| Parameter | Statin users (N=276) | Statin non-users (N=348) | p Value |
|---|---|---|---|
| Mean age, years (SD) | 68.2 (7.0) | 66.3 (7.8) | 0.0014 |
| Sex, n (%) | |||
| Male | 225 (81.5) | 240 (69.0) | 0.0004 |
| Mean % predicted FVC (SD) | 72.5 (14.0) | 71.6 (13.3) | 0.4297 |
| Mean % predicted DLco* (SD) | 45.4 (10.3) | 45.7 (11.7) | 0.7329 |
| Mean 6MWD*, m (SD) | 407.4 (89.8) | 415.3 (97.6) | 0.3028 |
| Mean UCSD-SOBQ score* (SD) | 34.3 (22.1) | 35.4 (21.2) | 0.5325 |
| Medical history, n (%) | |||
| Cardiovascular disease | 127 (46.0) | 53 (15.2) | <0.0001 |
| Chronic renal failure | 13 (4.7) | 7 (2.0) | 0.0573 |
| COPD | 14 (5.1) | 8 (2.3) | 0.0621 |
| Cardiovascular risk factors, n (%) | |||
| Hypercholesterolaemia | 234 (84.8) | 61 (17.5) | <0.0001 |
| Smoker (current/former) | 186 (67.4) | 198 (56.9) | 0.0074 |
| Hypertension | 183 (66.3) | 157 (45.1) | <0.0001 |
| Obesity† | 125 (45.3) | 140 (40.2) | 0.2041 |
| Diabetes | 75 (27.2) | 59 (17.0) | 0.0020 |
*Statin users with missing values: DLco, n=1; 6MWD, n=4; UCSD-SOBQ, n=4. Statin non-users with missing values: DLco, n=1; 6MWD, n=5; UCSD-SOBQ, n=3.
†Defined as a body mass index >30 kg/m2.
6MWD, 6-minute walk distance; DLco, carbon monoxide diffusing capacity; UCSD-SOBQ, The University of California in San Diego Shortness of Breath Questionnaire.