Baseline demographic and clinical characteristics of randomised study participants
| Characteristic | Control (n=41) | PSALTI (n=34) | p Value |
|---|---|---|---|
| Age (years) | 56 (48–67) | 61 (53–67) | 0.239 |
| Female, n (%) | 26 (63) | 25 (71) | 0.459 |
| Cough duration (months) | 48 (24–126) | 60 (30–126) | 0.279 |
| FEV1 (L, observed), mean (SD) | 2.7 (0.9) | 2.6 (0.7) | 0.517 |
| FEV1/FVC (%), mean (SD) | 76 (8.2) | 76 (5.0) | 0.686 |
| LCQ, mean(SD) | 11.9 (3.5) | 10.4 (3.6) | 0.073 |
| Cough severity VAS | 65 (40–83) | 63 (49–75) | 0.652 |
| SF-36 PCS, | 47.1 (41.7–53.6) | 41.1 (35.6–49.1) | 0.033* |
| SF-36 MCS | 47.7 (38.3–54.9) | 49.9 (40.5–57.0) | 0.763 |
| HADS—Anxiety | 7 (3–10) | 7 (4–10) | 0.785 |
| HADS—Depression | 4 (1–8) | 5 (2–6) | 0.620 |
| VPQ | 17 (11–22) | 21 (13–27) | 0.158 |
| CFper hour† | 17.0 (0.4) | 17.0 (0.4) | 0.983 |
| C2 (µm)† | 4.01(0.69) | 4.74 0.62) | 0.677 |
| C5 (µm)† | 9.33 (0.56) | 8.25 (0.51) | 0.708 |
Data presented as median (IQR) unless otherwise stated.
*p<0.05.
†Geometric mean (log SD).
C2, capsaicin cough challenge—concentration that resulted in two or more coughs; C5, capsaicin cough challenge—concentration that resulted in five or more coughs; CFper hour, cough frequency per hour over a 24-hour period; HADS, Hospital Anxiety and Depression Scale; LCQ, Leicester Cough Questionnaire; MCS, mental component score; PCS, physical component score; PSALTI, physiotherapy, and speech and language therapy intervention; SF-36, short form 36 questionnaire; VAS, visual analogue scale; VPQ, vocal performance questionnaire.