Summary of odds ratios for comparison of comorbidity risk between severe asthma and rhinitis cohorts
| Severe Asthma Cohort vs Rhinitis (Non-Asthma) Cohort – Odds Ratio (95% Confidence Intervals) | |||||||
|---|---|---|---|---|---|---|---|
| Gender | Age-group | ||||||
| Male | Female | ≤45 yr | 46–60 yr | 61–70 yr | >70 yr | ||
| Type 2 Diabetes | 1.0 (0.6–1.6) | 2.7 (1.8–4.1)*** | 4.2 (1.1–18.0)** | 4.0 (2.2–7.2)*** | 1.7 (0.9–3.2) | 0.9 (0.5–1.6) | |
| Obesity | 1.8 (1.3–2.4)*** | 2.8 (2.2–3.5)*** | 3.7 (2.4–5.6)*** | 3.3 (2.4–4.6)*** | 1.8 (1.3–2.6)*** | 1.8 (1.3–2.6)*** | |
| Osteoporosis† | 49.2 (11.2–217)*** | 4.6 (3.2–6.8)*** | 18.3 (6.4–52.8)*** | 6.2 (3.0–12.6)*** | 5.2 (4.0–6.9)*** | ||
| Osteopenia† | ‡ | 4.5 (2.8–7.3)*** | 50.4 (12.0–210)*** | 2.7 (1.2–6.3)*** | 3.1 (1.5–6.6)*** | ||
| Hypertension | 1.9 (1.4–2.6)*** | 1.7 (1.3–2.2)*** | 4.1 (1.9–8.9)*** | 2.4 (1.6–2.4)*** | 1.7 (1.2–2.5)*** | 1.2 (0.9–1.7) | |
| Chronic Kidney Disease† | 3.9 (2.4–6.4)*** | 1.9 (1.3–2.7)*** | 7.7 (3.6–16.8)*** | 3.2 (1.7–5.9)*** | 1.4 (1.0–2.1)* | ||
| Dyspeptic Disorders | 5.5 (4.0–7.6)*** | 7.8 (5.9–10.3)*** | 9.4 (5.8–15.2)*** | 9.8 (6.5–14.7)*** | 6.2 (3.9–9.8)*** | 4.0 (3.3–4.8)*** | |
| Psychiatric Disorders | 1.6 (1.2–2.2)*** | 2.0 (1.6–2.6)*** | 2.6 (1.8–3.9)*** | 2.1 (1.6–2.9)*** | 1.8 (1.2–2.5)*** | 1.3 (0.9–2.0) | |
| Sleep Disorders | 1.2 (0.4–3.4) | 3.5 (1.9–6.7)*** | 12.9 (1.6–103 )** | 8.1 (2.1–30.3)*** | 2.3 (0.7–7.5) | 0.6 (0.2–1.8) | |
| Hypercholesterolemia | 2.1 (1.4–3.1)*** | 1.4 (1.0–1.9)* | ‡ | 2.2 (1.3–3.8)*** | 1.7 (1.1–2.8)** | 1.2 (0.8–1.8) | |
†Age groups ‘<45 yr’ and ‘46–60 yr’ were combined
‡Too few cases of comorbidity for analysis
* P<0.1, ** P<0.05, ***P<0.01