Table 5

Summary data for long-term psychosocial outcomes (T2) by trial arm and screening outcome

Outcome (T2)Intervention
(n=1553)
Control
(n=1302)
Intervention arm (n=1553) by screening outcome†
True-negative
(n=740)
Incidental finding
(n=78)
False-positive
(n=445)
True-positive
(n=23)
Cancer distress‡
M (95% CI)
Low T0 scorers
2.10 (2.09 to 2.11)
8.15 (8.05 to 8.25)
Low T0 scorers
2.09 (2.08 to 2.10)
8.10 (7.99 to 8.25)

2.11 (2.09 to 2.12)
8.22 (8.09 to 8.36)

2.14 (2.09 to 2.19)
8.48 (8.06 to 8.93)

2.14 (2.12 to 2.16)
8.51 (8.33 to 8.70)

2.20 (2.10 to 2.30)
9.01 (8.16 to 9.96)
High T0 scorers
2.44 (2.39 to 2.48)
11.43 (10.93 to 11.95)
High T0 scorers
2.46 (2.41 to 2.51)
11.69 (11.11 to 12.30)
Anxiety‡
M (95% CI)

1.54 (1.51 to 1.57)
3.66 (3.52 to 3.80)

1.61 (1.58 to 1.65)**
4.02 (3.86 to 4.19)

1.57 (1.53 to 1.62)
3.82 (3.61 to 4.03)

1.45 (1.32 to 1.59)
3.28 (2.74 to 3.89)

1.52 (1.47 to 1.58)
3.59 (3.34 to 3.85)

1.37 (1.13 to 1.62)
2.94 (2.08 to 4.03)
Depression‡
M (95% CI)

1.33 (1.30 to 1.36)
2.77 (2.67 to 2.89)

1.39 (1.36 to 1.42)*
3.01 (2.89 to 3.14)

1.34 (1.30 to 1.39)
2.84 (2.68 to 3.00)

1.22 (1.09 to 1.35)
2.38 (1.97 to 2.85)

1.38 (1.33 to 1.44)
2.98 (2.78 to 3.20)

1.26 (1.02 to 1.49)
2.52 (1.79 to 3.44)
Decision satisfaction (n, %)
Not very satisfied
Very satisfied

855 (60)
567 (40)

883 (74)**
306 (26)

411 (61)
267 (39)

39 (55)
32 (45)

239 (59)
169 (41)

6 (29)§
15 (71)
  • *p≤0.01, **p≤0.001.

  • Ns vary in each cell due to missing data.

  • †n=267 were excluded at T2 if they had no baseline scan, had a MDT referral but no lung cancer diagnosed, were awaiting scan or results, or had results that were not classified.

  • ‡Logn scores are provided in normal text and original scale scores are provided in italics (analyses performed using logn scores). Estimated marginal means are presented. Higher scores denote higher levels of the relevant outcome.

  • §Test statistics not calculated due to low variation.