Baseline measurements and changes with treatment related to the primary and secondary outcomes of pulmonary function and blood pressure measures
| Baseline, mean (SD)/median (IQR) | Intra-group differences, mean (95% CI) | p Value of inter-group differences§ | ||||
|---|---|---|---|---|---|---|
| NIV | Control | NIV | Control | Unadjusted | Adjusted | |
| PaCO2, mm Hg | 49 (4.0) | 49 (3.5) | −6 (−7.7 to −4.2)‡ | −2.8 (−4.3 to −1.3)‡ | 0.006 | 0.019 |
| Serum bicarbonate, mmol/L | 30 (4.1) | 29 (3.8) | −3.4 (−4.5 to −2.3)‡ | −1 (−1.7 to −0.2)* | 0.000 | 0.004 |
| pH | 7.400 (0.040) | 7.400 (0.030) | 0.005 (−0.005 to 0.157) | 0.031 (−0.008 to 0.147) | NS | – |
| PaO2, mm Hg | 64 (10) | 67 (10) | 4.6 (0.5 to 8.8)* | 1.4 (−2.6 to 5.5) | NS | – |
| FEV1, % | 72 (16) | 80 (20) | 1.8 (−2.7 to 6.4) | 1.9 (−1.2 to 5.1) | NS | – |
| FVC, % | 75 (21) | 82 (20) | 4.7 (−4.2 to 14) | 2.9 (−0.5 to 6.3) | NS | – |
| 6-MWD, m | 309 (105) | 349 (105) | 29 (−16 to 74) | −7.2 (−25 to 11) | NS | – |
| Systolic BP, mm Hg | 136 (18) | 136 (15) | −4.2 (−11 to 2.5) | −4.3 (−10 to 1.7) | NS | – |
| Diastolic BP, mm Hg | 80 (16) | 80 (18) | 0.5 (−5.3 to 6.2) | −1.2 (−5.4 to 2.9) | NS | – |
Median (IQR) values are shown in italic.
Bold type indicates statistical significance.
p Values of intra-group differences (2 months − baseline): *p<0.05; †p<0.01; ‡p<0.001. §p Values of inter-group differences unadjusted or adjusted by basic adjustment (baseline values of the variable analysed and age, gender, BMI and AHI).
6-MWD, 6 min walk distance; AHI, apnoea–hypopnoea index; BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; NIV, non-invasive ventilation.