Table 4

Associations (coefficient and 95% CI) between birth weight and FEV1 (mL) and FVC (mL) at age 43 years, 53 years and 60–64 years in women

WomenFEV1 (mL)
Birth weight (per 1 kg increase)Age 43 years (N=1451)Age 53 years (N=1218)Age 60–64 years (N=932)
M0: unadjusted136.1(92 to 180.2)69.4(21.8 to 117.0)76.8(21.8 to 131.7)
M1: M0+adult height*60.6(19.3 to 101.9)−10.7(−55.1 to 33.6)1.8(−50.6 to 54.3)
M2: M1+adult covariates†46.8(1.7 to 92.0)7.3(−41.9 to 56.4)13.7(−47.7 to 75.2)
M3: M2+early life covariates‡51.0(−1.2 to 103.2)29.9(−26.3 to 86.1)19.8(−47.7 to 87.2)
FVC (mL)
Birth weight (per 1 kg increase)Age 43 years (N=1448)Age 53 years (N=1175)Age 60–64 years (N=911)
M0: unadjusted189(129.8 to 248.3)79.7(19.2 to 140.2)96.4(28.7 to 164)
M1: M0+adult height*86.8(31.3 to 142.3)−19.6(−73.7 to 34.6)−16.9(−79.0 to 45.1)
M2: M1+adult covariates†63.9(2.6 to 125.1)−4.5(−66.2 to 57.2)−23.1(−96.0 to 49.9)
M3: M2+early life covariates‡64.2(−5.0 to 133.3)2.3(−68.3 to 72.9)−31.4(−111.7 to 49.0)
  • Bold indicates where significance level is P<0.05.

  • *Adjusted for age at 2006–2010 follow-up (age 60–64 years).

  • †Adult covariates included education level, smoking status, asthma status, smoking pack years.

  • ‡Early life covariates included weight gain at age 2 years, lower respiratory tract infections under age 2 years and childhood social class at age 4 years.