Table 3

Associations (coefficient and 95% CI) between birth weight and FEV1 (mL) and FVC (mL) at age 43 years, 53 years and60–64 years in men

MenFEV1 (mL)
Birth weight (per 1 kg increase)Age 43 years (N=1385)Age 53 years (N=1174)Age 60–64 years (N=856)
M0: unadjusted128.0(67.7 to 188.4)110.7(49.8 to 171.6)136.1(60.6 to 211.6)
M1: M0+adult height*17.6(−40.4 to 75.5)2.1(−55.6 to 59.7)8.9(−64.7 to 82.5)
M2: M1+adult covariates†1.1(−63.2 to 65.4)26.3(−35.6 to 88.2)27.4(−55.2 to 109.9)
M3: M2+early life covariates‡28.4(−44.9 to 101.7)34.6(−35.2 to 104.3)63.0(−31.2 to 157.2)
FVC (mL)
Birth weight (per 1 kg increase)Age 43 years (N=1326)Age 53 years (N=1060)Age 60–64 years (N=777)
M0: unadjusted187.7(103.1 to 272.2)224.6(143.8 to 305.5)128.3(31.7 to 224.9)
M1: M0+adult height*30.1(−50.2 to 110.5)66.8(−7.55 to 141.1)−50.5(−141.2 to 40.3)
M2: M1+adult covariates†−3.8(−95.7 to 88.1)74.4(−11.8 to 160.7)−15.3(−123.2 to 92.6)
M3: M2+early life covariates‡10.8(−93.4 to 115.1)113.6(19.2 to 208.0)23.4(−101.9 to 148.7)
  • Bold indicates where significance level is P<0.05.

  • *Adjusted for age at 2006–2010 follow-up (age 60–64 years).

  • †Adult covariates included education level, smoking status, asthma status, smoking pack years.

  • ‡Early life covariates included weight gain at age 2 years, lower respiratory tract infections under age 2 years and childhood social class at age 4 years.