COPD subjects with severe PH | COPD subjects without severe PH | p Value | |
---|---|---|---|
N | 20 | 20 | |
Age | |||
Years | 67±9 | 66±8 | 0.766 |
Sex ratio | |||
Men/women | 17/3 | 15/5 | 0.693 |
BMI | |||
kg/m2 | 26±5 | 24±4 | 0.123 |
Tobacco | |||
Smoking status (Y/N) | 20/0 | 20/0 | |
Current smoker (Y/N) | 5/15 | 7/13 | 0.731 |
Pack year (no) | 31 (11–47) | 31 (25–40) | 0.978 |
PFT | |||
FEV1 (% pred) | 52±21 | 52±21 | 0.983 |
FEV1/FVC (%) | 54±15 | 50±15 | 0.380 |
TLC (%) | 99 (92–105) | 107 (94–130) | 0.182 |
RV (%) | 124 (98–148) | 134 (102–225) | 0.579 |
TLCO (%) | 24±10 | 40±22 | 0.008 |
Six-minute walk test | |||
Distance (m) | 271±100 | 370±68 | 0.003 |
Arterial blood gases (ambient air) | |||
PaO2 (mm Hg) | 51±6 | 59±13 | 0.014 |
PaCO2 (mm Hg) | 36 (29–41) | 37 (34–43) | 0.228 |
Right heart catheterisation | |||
mPAP (mm Hg) | 45±6 | 25±5 | <0.001 |
sPAP (mm Hg) | 70±14 | 39±8 | <0.001 |
dPAP (mm Hg) | 28±4 | 15±4 | <0.001 |
PCWP (mmHg) | 9±2 | 7±3 | 0.012 |
Gradient (mm Hg) | 20±4 | 9±3 | <0.001 |
PVR (Wood unit) | 8±2 | 4±1 | <0.001 |
PVRi (Wood unit/m2) | 14±5 | 7±1 | <0.001 |
Cardiac output (L/min) | 5±1.2 | 5±1.2 | 0.557 |
Cardiac index (L/min/m2) | 3±0.7 | 3±0.5 | 0.556 |
Biology | |||
CRP (pg/mL) | 5±3 | 6±2 | 0.377 |
BNP (mg/mL) | 481±114 | 177±215 | 0.019 |
Severe PH in COPD is defined mPAP ≥35 mm Hg, without <35 mm Hg. Data are means±SD for continuous normal variables, or median with IQR if their distribution is not normal. Comparisons of continuous variables were made with the t tests or with Mann–Whitney tests for non-parametric variables. Categorical variables were analysed with Fisher's exact tests.
BMI, body mass index; BNP, brain natriuretic peptide; CRP, C reactive protein; Gradient, dPAP-PCWP; m, s, dPAP, mean, systolic, diastolic pulmonary arterial pressure; PCWP, pulmonary capillary wedge pressure; PFT, pulmonary function test; PH, pulmonary hypertension; pred, predicted; PVR, pulmonary vascular resistance; PVRi, indexed PVR; RV= residual volume; TLC= total lung capacity; TLCO= transfert lung capacity of carbon monoxide.