Accuracy of the seven-marker serum protein biosignature (apolipoprotein (Apo)A-1, complement factor H (CFH), C reactive protein (CRP), interferon (IFN)-γ, inducible protein (IP)-10, serum amyloid A (SAA), transthyretin) in the diagnosis of TB disease regardless of HIV infection status
| Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|
| Training set (n=491) | ||||
| %, (n/N) 95% CI | 86.7 (130/150) (79.9 to 91.5) | 85.3 (291/341) (81.0 to 88.8) | 72.2 (65.0 to 78.5) | 93.6 (90.1 to 95.9) |
| Test set (n=210) | ||||
| %, (n/N) 95% CI | 81.3 (52/64) (69.2 to 89.5) | 79.5 (116/146) (71.8 to 85.5) | 63.4 (52.0 to 73.6) | 90.6 (83.9 to 94.8) |
| Accuracy of biosignature after selection of cut-off values optimised for sensitivity | ||||
| %, (n/N) 95% CI | 90.7 (136/150) (84.5 to 94.6) | 74.8 (255/341) (69.8 to 79.2) | 61.3 (54.5 to 67.6) | 94.8 (91.2 to 97.0) |
| Test set (n=210) | ||||
| %, (n/N) 95% CI | 93.8 (60/64) (84.0 to 98.0) | 73.3 (107/146) (65.2 to 80.1) | 60.6 (50.3 to 70.1) | 96.4 (90.5 to 98.8) |
NPV, negative predictive value; PPV, positive predictive value.