Multivariate analysis of mPAP in patients with COPD with and without severe PH
| Population studied | Model | Independent variables | Partial R2 | Increase in mPAP per unit increase in independent variable (mm Hg) | p Value |
|---|---|---|---|---|---|
| COPD subjects with severe PH | R2=0.65; p<0.007 | PaO2 | 0.03 | −0.18 | 0.250 |
| F=9.6 | WT | 0.29 | 26.3 | 0.002 | |
| (n=20) | Mean square error=19.6 | %CSA<5 | 0.36 | 21.1 | 0.001 |
| COPD subjects without severe PH | R2=0.69; p<0.0002 | PaO2 | 0.13 | −0.17 | 0.020 |
| F=12.1 | WT | 0.26 | 22.0 | 0.002 | |
| (n=20) | Mean square error =12.34 | %CSA<5 | 0.09 | −13.5 | 0.040 |
Severe PH in COPD is defined as mPAP ≥35 mm Hg, without <35 mm Hg.
%CSA<5, percentage of total lung area taken up by the cross-sectional area of pulmonary vessels less than 5 mm2; mPAP, mean pulmonary arterial pressure; PH, pulmonary hypertension; WT, mean wall thickness (mm).