Table 2

Characteristics of the children hospitalised for severe bronchiolitis according to the profiles (A to D) identified by LCA, for additional sociodemographic and clinical characteristics not introduced in the LCA model, MARC-30 USA, n=2207

	All	Profiles				p Value
	All	A (12%)	B (36%)	C (34%)	D (17%)	p Value
Age (months)
<2	28	7	20	37	45	<0.001
2–5.9	35	22	41	36	30
6–11.9	22	41	24	18	15
≥12	14	30	15	9	10
Girls	41	33	41	40	45	0.01
Race
White	61	57	60	61	69	<0.001
Black/African-American	24	32	25	23	21
Other	14	11	15	16	10
Hispanic ethnicity	36	32	38	34	40	0.07
Parental history of asthma	31	37	32	31	27	0.08
ED presentation
Fever	29	23	30	32	27	0.05
Apnoea	7	6	4	10	10	<0.001
Inadequate oral intake	50	38	46	60	45	<0.001
ICU and intubation/CPAP
No ICU	82	86	94	64	88	<0.001
ICU without intubation/CPAP	11	11	5	18	8
ICU with intubation/CPAP	7	3	1	17	4
Viral aetiology
RSV only	49	0	65	52	46	<0.001
Rhinovirus only	8	38	0	3	10
RSV and rhinovirus	13	8	10	20	9
RSV and other non-rhinovirus	10	0	15	10	6
Rhinovirus and other non-RSV	5	27	0	2	5
Non-RSV and non-rhinovirus	15	28	9	13	24
Number of pathogens
No pathogen identified	6	10	4	6	10	<0.001
1	64	53	71	61	65
2	24	29	22	27	20
≥3	5	8	4	6	4

Results presented as %.
Profile A: history of wheezing/eczema, wheezing at ED presentation, more often rhinovirus. Profile B: wheezing at ED presentation, more often RSV only. Profile C: most severe. Profile D: non-wheezing at ED presentation, least severe.
CPAP, continuous positive airway pressure; ED, emergency department; ICU, intensive care unit; LCA, latent class analysis; RSV, respiratory syncytial virus.