Factors associated with TB clustering; a multivariable logistic regression analysis, universal MIRU-VNTR, London 2010–2012
| Variable | Adjusted OR (95% CI) | p Value* |
|---|---|---|
| Gender | ||
| Female | Reference | |
| Male | 1.2 (1.0 to 1.3) | 0.02 |
| Age | ||
| 0–4 | 3.6 (0.8 to 17.5) | 0.11 |
| 5–9 | 1.0 (0.3 to 3.7) | 0.97 |
| 10–14 | 1.0 (0.6 to 1.8) | 1.00 |
| 15–19 | 1.2 (0.9 to 1.7) | 0.15 |
| 20–29 | Reference | |
| 30–39 | 0.9 (0.8 to 1.1) | 0.31 |
| 40–49 | 0.7 (0.6 to 0.9) | <0.01 |
| 50–59 | 0.8 (0.6 to 1.0) | 0.09 |
| 60–69 | 1.0 (0.8 to 1.4) | 0.83 |
| >70 | 0.7 (0.5 to 1.0) | 0.04 |
| UK/non-UK born and ethnicity | ||
| UK born | ||
| Indian | 1.9 (1.1 to 3.3) | 0.02 |
| Pakistani | 1.7 (0.8 to 3.5) | 0.18 |
| Bangladeshi | 1.5 (0.7 to 3.4) | 0.35 |
| White | 2.3 (1.7 to 3.2) | <0.01 |
| Black-Caribbean | 6.7 (3.7 to 12.2) | <0.01 |
| Black-African | 4.4 (2.6 to 7.6) | <0.01 |
| Other | 4.0 (2.1 to 7.5) | <0.01 |
| Non-UK born | ||
| Indian | Reference | |
| Pakistani | 1.1 (0.9 to 1.4) | 0.38 |
| Bangladeshi | 0.5 (0.3 to 0.7) | <0.01 |
| White | 1.0 (0.7 to 1.5) | 0.85 |
| Black-Caribbean | 3.3 (1.8 to 5.8) | <0.01 |
| Black-African | 1.8 (1.5 to 2.2) | <0.01 |
| Other | 1.0 (0.8 to 1.2) | 0.91 |
| Social risk factors | ||
| Homelessness | ||
| Yes | 0.8 (0.5 to 1.2) | 0.30 |
| No | Reference | |
| Drug misuse | ||
| Yes | 1.6 (1.0 to 2.4) | 0.03 |
| No | Reference | |
| Alcohol misuse and prison history | ||
| Yes | 3.3 (1.2 to 9.3) | 0.03 |
| No | Reference | |
| Clinical presentation | ||
| Extrapulmonary | Reference | |
| Pulmonary smear negative | 1.4 (1.2 to 1.7) | <0.01 |
| Pulmonary smear positive | 1.5 (1.3 to 1.8) | <0.01 |
| Pulmonary smear status unknown | 1.3 (1.0 to 1.6) | 0.04 |
| Previous TB | ||
| Yes | 2.1 (1.5 to 3.0) | <0.01 |
| No | Reference | |
| MDR TB | ||
| Yes | 1.2 (0.7 to 2.0) | 0.54 |
| No | Reference | |
*Significant results are in bold.
MDR, multi drug resistant; MIRU-VNTR, multiple interspersed repetitive units-variable number tandem repeats.