Table 1

Predicted pharmacodynamics of GSK2126458 in idiopathic pulmonary fibrosis patients by dose (Max: maximum inhibition (%), Min: minimum inhibition (%))

Dose (mg), twice daily	pAkt/Akt		Proliferation		BAL
Dose (mg), twice daily	Max	Min	Max	Min	Max	Min
0.25	14.3	8.3	24.5	19.2	24.2	12.4
1	35.8	23.2	36.4	30.4	62.5	45.7
2	49.6	34.9	42.5	37.1	76	65.2
2.5	54.1	38.7	44.6	39.6	79	69.7