Severity of airflow limitation, adjusted for pack-years (n=2517) | UK BiLEVE pack-years adjusted analysis (n=4231) | Meta-analysis of discovery and UK BiLEVE pack-year adjusted analyses | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
rs no. | CHR | Position | Coded allele | Gene | MAF (MAC) | Beta (95% CI) | p Value | MAF (MAC) | Beta (95% CI) | p Value | Beta (95% CI) | p Value |
rs140198372 | 14 | 94953832 | A | SERPINA12 (splice site) | 0.059% (3) | −29.23 (−49.50 to −8.96) | 2.59×10−5 | 0.012% (1) | −38.35 (−59.88 to −16.82) | 4.11×10−4 | −33.51 (−48.27 to −18.76) | 5.72×10−6 |
*p Values in bold significant at p<10−5 level.
BiLEVE, Biobank Lung Exome Variant Evaluation; MAC, minor allele count; MAF, minor allele frequency.