Obstructive | |||||
---|---|---|---|---|---|
Normal | Restrictive | Mild | Moderate | Severe | |
N=1582 | N=887 | N=235 | N=351 | N=137 | |
Mean FEV1,% predicted | 101 | 75 | 95 | 66 | 39 |
Range, % | 74–193 | 15–106 | 88–219 | 55–122 | 29–125 |
Mean FEV1(SD), L | 3.04 (0.48) | 2.25 (0.49) | 2.80 (0.53) | 1.96 (0.34) | 1.14 (0.27) |
Mean FVC, % Predicted | 96 | 67 | 101 | 83 | 61 |
Range, % | 80–156 | 12–79 | 88–219 | 55–122 | 29–125 |
Mean FVC (SD), L | 3.82 (0.59) | 2.67 (0.56) | 4.32 (0.80) | 3.25 (0.61) | 2.39 (0.83) |
Mean difference (95% CI) in log NT-proBNP (pg/mL) | |||||
Age-adjusted | 0 | 0.16 (0.08 to 0.24)* | −0.03 (−0.17 to 0.11) | 0.20 (0.19 to 0.11)* | 0.21 (0.04 to 0.39)* |
Model 1 | 0 | 0.12 (0.04 to 0.20)* | −0.05 (−0.17 to 0.08) | 0.16 (0.05 to 0.27)* | 0.17 (0.01 to 0.32)* |
Model 2 | 0 | 0.08 (0.003 to 0.16)* | −0.06 (−0.19 to 0.07) | 0.11 (0.002 to 0.22)* | 0.08 (−0.09 to 0.25) |
Mean difference (95% CI) in log cTnT (pg/mL)) | |||||
Age-adjusted | 0 | 0.10 (0.07 to 0.14)* | −0.02 (−0.08 to 0.37) | 0.00 (−0.05 to 0.05) | 0.11 (0.04 to 0.19)* |
Model 1 | 0 | 0.08 (0.06 to 0.10)* | −0.02 (−0.08 to 0.04) | −0.01 (−0.05 to 0.04) | 0.11 (0.04 to 0.19)* |
Model 2 | 0 | 0.07 (0.05 to 0.09)* | −0.02 (−0.08 to 0.04) | −0.01 (−0.06 to 0.04) | 0.08 (0.004 to 0.16)* |
Normal used as the reference group.
Model 1=adjusted for age, smoking status, physical activity, heavy drinking, social class, body mass index, left ventricular hypertrophy, systolic blood pressure, use of antihypertensive drugs, diabetes, stroke and atrial fibrillation.
Model 2=model 1+ C-reactive protein.
*Significantly different from the normal group (p<0.05); normal=FEV1/FVC≥0.70 and FVC≥80% and not on bronchodilators.