Table 4

Mean lung function and the difference in mean level of log N terminal pro-brain natriuretic peptide (NT-proBNP) and log cardiac troponin T (cTnT) in men with restrictive and obstructive lung patterns compared with men with normal lung pattern in men with no prior heart failure or myocardial infarction

 Obstructive
NormalRestrictiveMildModerateSevere
N=1582N=887N=235N=351N=137
Mean FEV1,% predicted10175956639
Range, %74–19315–10688–21955–12229–125
Mean FEV1(SD), L3.04 (0.48)2.25 (0.49)2.80 (0.53)1.96 (0.34)1.14 (0.27)
Mean FVC, % Predicted96671018361
Range, %80–15612–7988–21955–12229–125
Mean FVC (SD), L3.82 (0.59)2.67 (0.56)4.32 (0.80)3.25 (0.61)2.39 (0.83)
Mean difference (95% CI) in log NT-proBNP (pg/mL)
Age-adjusted00.16 (0.08 to 0.24)*−0.03 (−0.17 to 0.11)0.20 (0.19 to 0.11)*0.21 (0.04 to 0.39)*
Model 100.12 (0.04 to 0.20)*−0.05 (−0.17 to 0.08)0.16 (0.05 to 0.27)*0.17 (0.01 to 0.32)*
Model 200.08 (0.003 to 0.16)*−0.06 (−0.19 to 0.07)0.11 (0.002 to 0.22)*0.08 (−0.09 to 0.25)
Mean difference (95% CI) in log cTnT (pg/mL))
Age-adjusted00.10 (0.07 to 0.14)*−0.02 (−0.08 to 0.37)0.00 (−0.05 to 0.05)0.11 (0.04 to 0.19)*
Model 100.08 (0.06 to 0.10)*−0.02 (−0.08 to 0.04)−0.01 (−0.05 to 0.04)0.11 (0.04 to 0.19)*
Model 200.07 (0.05 to 0.09)*−0.02 (−0.08 to 0.04)−0.01 (−0.06 to 0.04)0.08 (0.004 to 0.16)*
  • Normal used as the reference group.

  • Model 1=adjusted for age, smoking status, physical activity, heavy drinking, social class, body mass index, left ventricular hypertrophy, systolic blood pressure, use of antihypertensive drugs, diabetes, stroke and atrial fibrillation.

  • Model 2=model 1+ C-reactive protein.

  • *Significantly different from the normal group (p<0.05); normal=FEV1/FVC≥0.70 and FVC≥80% and not on bronchodilators.