Performance characteristics of the best individual and ensemble classifier panels to predict imminent cystic fibrosis pulmonary exacerbations (ie, <4 months post-stable visit)
| Classifier panel | Discovery cohort (n=70) | Replication cohort (n=34) | ||||
|---|---|---|---|---|---|---|
| AUC | Sensitivity (%) | Specificity (%) | AUC | Sensitivity (%) | Specificity (%) | |
| Best clinical panel* | 0.55 | 90 | 8 | 0.63 | 100 | 10 |
| Best candidate protein panel† | 0.61 | 90 | 35 | 0.55 | 85 | 24 |
| MRM-MS panel‡ | 0.74 | 90 | 45 | 0.73 | 92 | 48 |
| CRP+FEV1% | 0.61 | 90 | 13 | 0.67 | 92 | 19 |
| MRM-MS+FEV1% | 0.71 | 90 | 35 | 0.76 | 100 | 24 |
*FEV1 % predicted alone.
†CRP alone.
‡CRP, peroxiredoxin-2, haemoglobin subunit alpha, carbonic anhydrase 1, CD5, apolipoprotein C-II.
AUC, area under the curve; CRP, C-reactive protein; MRM-MS, multiple reaction monitoring mass spectrometry.