Table 4

Doses of medication to be used and anticipated time to assess if there has been a clinical response

chILD ventilated or close to ventilationchILD not ventilated or close to ventilation
Methylprednisolone
 DoseIntravenous 10 mg/kg or 500 mg/m2Intravenous 10 mg/kg or 500 mg/m2
 Response rate7 days28 days
 Comment30 mg/kg used by some centresAs alternative to oral prednisolone. Use before other therapies and judge response
Prednisolone
 DoseOral 1 mg/kg, used in between pulses of methylprednisoloneOral 2 mg/kg, as alternative to methylprednisolone pulses. Use before other therapies and judge response
 Response rate7 days28 days
Hydroxychloroquine
 Dose10 mg/kg10 mg/kg
 Response rate21–28 days3 months
 CommentIn children <6 years 6.5 mg/kg in some centres to reduce toxicityIn children <6 years 6.5 mg/kg in some centres to reduce toxicity.
No preference over azithromycin as second line.
54% would consider Hydroxychloroquine as sole therapy in mild stable chILD
Azithromycin
 Dose10 mg/kg 3 days per week10 mg/kg 3 days per week
 Response rate3 months3 months.
 CommentNo preference over hydroxychloroquine as second line.
51% would consider azithromycin as sole therapy in mild stable chILD
  • Results are simple majority assessed by median?/mean?.

  • chILD, childhood interstitial lung disease; IV, intravenous; PIG, pulmonary interstitial glycogenosis.