Demographical and lung function data at baseline and after methacholine challenge
| Non-asthmatic | Asthmatic | |
|---|---|---|
| Age (years) | 29±4 | 28±9 |
| Sex (male/female) | 5/2 | 9/0 |
| Atopy (yes/no) | 1/6 | 9/0 |
| Upright Rrs baseline (% predicted) (screening) | 122±19 | 202±93 |
| Supine Rrs baseline (% predicted) | 108±25 | 211±104* |
| Increase in Rrs post-challenge (% baseline) | 89±24 | 58±43 |
| Increase in Rrs post-challenge (absolute) | 2.7±0.9 | 2.7±1.6 |
| Upright FEV1 baseline (% predicted) | 97±12 | 79±14* |
| Supine FEV1 baseline (% predicted) | 93±11 | 75±14‡ |
| Decrease in supine FEV1 post-challenge (% baseline) | 32±14 | 27±13 |
| Decrease in supine FEV1 post-challenge (mL) | 1240±458 | 850±488 |
| Supine IC post-laboratory challenge (L) | 3.38±0.14 | 3.20±0.16 |
| Supine IC post-HRCT challenge (L) | 3.35±0.25 | 3.30±0.16 |
| Methacholine dose administered (μmol) | 25.8±21.3 | 0.6±0.9^ |
All values are mean±SD. All values are taken from the scanning visit, except for upright Rrs, which was collected at the screening visit.
*p=0.020; ^p=0.003; ‡p=0.025.
HRCT, high-resolution CT; IC, inspiratory capacity; Rrs, respiratory system resistance.