Cluster associations with COPD-related measures and COPD SNPs in training and validation data for core feature set cluster solution, k = 4
| Training | Validation | |||||
|---|---|---|---|---|---|---|
| C2: OR (95% CI) | C3: OR (95% CI) | C4: OR (95% CI) | C2: OR (95% CI) | C3: OR (95% CI) | C4: OR (95% CI) | |
| Exacerbations | 2.27 (1.97 to 2.61)*** | 3.16 (2.82 to 3.55)*** | 8.93 (7.97 to 10.01)*** | 2.17 (1.90 to 2.49)*** | 2.66 (2.38 to 2.98)*** | 7.80 (7.00 to 8.70)*** |
| MMRC | 2.81 (2.57 to 3.07)*** | 3.39 (3.14 to 3.66)*** | 10.88 (10.00 to 11.83)*** | 2.02 (2.01 to 2.40)*** | 3.00 (2.78 to 3.23)*** | 10.07 (9.26 to 10.94)*** |
| BODE | 3.37 (3.06 to 3.70)*** | 4.63 (4.27 to 5.02)*** | 66.52 (60.06 to 73.67)*** | 2.62 (2.38 to 2.88)*** | 4.23 (3.90 to 4.58)*** | 52.64 (47.62 to 58.19)*** |
| Hospitalisations/ER visits | 4.07 (3.34 to 4.95)*** | 5.05 (4.24 to 6.01)*** | 11.82 (9.98 to 14.00)*** | 3.05 (2.53 to 3.68)*** | 4.13 (3.52 to 4.86)*** | 8.03 (6.86 to 9.39)*** |
| rs7671167 (FAM13A) | 0.95 (0.87 to 1.04)NS | 0.87 (0.81 to 0.93)* | 0.84 (0.78 to 0.91)* | 1.01 (0.92 to 1.10)NS | 0.89 (0.83 to 0.95)NS | 0.91 (0.85 to 0.98)NS |
| rs1980057 (HHIP) | 0.64 (0.58 to 0.70)*** | 0.92 (0.85 to 0.98)NS | 0.79 (0.73 to 0.85)*** | 0.80 (0.73 to 0.87)* | 1.09 (1.01 to 1.17)NS | 0.74 (0.69 to 0.80)*** |
| rs13180 (Chr15q25) | 0.82 (0.75 to 0.90)* | 1.04 (0.96 to 1.11)NS | 0.82 (0.76 to 0.88)** | 0.72 (0.66 to 0.79)*** | 0.99 (0.92 to 1.07)NS | 0.82 (0.76 to 0.88)** |
| rs8034191 (Chr15q25) | 1.33 (1.21 to 1.46)** | 1.03 (0.96 to 1.11)NS | 1.50 (1.39 to 1.61)*** | 1.30 (1.19 to 1.43)** | 0.89 (0.83 to 0.96)NS | 1.17 (1.09 to 1.26)* |
| rs7937 (Chr 19q13) | 1.30 (1.18 to 1.42)** | 1.16 (1.08 to 1.24)* | 1.20 (1.12 to 1.29)* | 1.08 (0.99 to 1.18)NS | 1.06 (0.99 to 1.14)NS | 1.46 (1.36 to 1.57)*** |
Effect sizes represent OR from logistic regression or proportional odds logistic regression in the case of exacerbations, MMRC score and BODE index.
In all instances, cluster 1 (ie, the cluster with the highest mean FEV1% of predicted) serves as the reference.
Effect allele for rs7671167 = C, rs1980057 = T, rs13180 = C, rs8034191=C, rs7937=T.
*0.01<p≤0.05; **0.001<p≤0.01; ***p≤0.001, NS p>0.05.