Table 4

Pulmonary function for SMO versus CON

ParametersLow altitudeAfter arrivalDay 33 months6 monthsPaPb
VC (l)SMO 4.48±0.46SMO 4.36±0.63SMO 4.24±0.60SMO 4.12±0.62SMO 4.10±0.380.046G: 0.110
CON 4.54±0.44CON 4.43±0.45CON 4.12±0.63CON 4.52±0.32*CON 4.50±0.26†0.013I: 0.027
FEV1 (l)SMO 3.92±0.82SMO 3.98±0.74SMO 4.02±0.84SMO 3.96±0.78SMO 3.82±0.740.321G: 0.164
CON 4.10±0.48CON 4.21±0.51CON 4.18±0.62CON 4.28±0.46‡CON 4.22±0.50‡0.388I: 0.465
FEF25–75% (litres/s)SMO 4.08±1.05SMO 4.01±0.85SMO 4.06±1.06SMO 4.02±1.12SMO 3.92±0.920.465G: 0.044
CON 4.16±0.85CON 4.24±0.66CON 4.28±0.72CON 4.81±0.63§CON 4.93±0.67¶0.006I: 0.048
MVV (litres/min)SMO 108.0±4.5SMO 110.2±4.4SMO 111.6±4.8SMO 106.3±5.2SMO 107.4±5.30.035G: 0.002
CON 111.3±5.2CON 115.5±5.6**CON 117.4±4.6**CON 118.3±3.8**CON 117.8±4.5**0.002I: 0.001
  • Data are presented as mean ± SD. Pa: ANOVA for repeated measures within each group separately. Pb: ANOVA—probabilities between groups (G), and interaction (I). Group comparisons: *SMO versus CON, p<0.001; †SMO versus CON p<0.001, ‡SMO versus CON, p=0.048 and p=0.036; §SMO versus CON, p=0.048; ¶SMO versus CON, p=0.021; **SMO versus CON, p<0.001.

  • Because of technical problems only a subset of subjects had pulmonary function tests: at low altitude 40 (SMO) and 42 (CON), after arrival 36 (SMO) and 28 (CON), at 3 days 36 (SMO) and 28 (CON), at 3 months 32 (SMO) and 34 (CON) and at 6 months 28 (SMO) and 25 (CON). The measurements reported concern the same subjects over time.

  • SMO, smoking group; CON, control group; VC, vital capacity; FEV1, forced expiratory volume in 1 s; FEF25-75% forced expiratory flow between 25% and 75% of vital capacity; MVV, maximal voluntary ventilation.