Changes in inflammatory markers from baseline to 14 days according to treatment assignment
| Inflammatory marker | Etanercept | Prednisone | Between-group difference | p Value |
|---|---|---|---|---|
| Change in CRP (mg/l), mean (SD) | −14.1 (29.0) | −7.7 (83.4) | 6.5 (62.1) | 0.66 |
| Change in serum TNFα (pg/ml), (95% CI) | 6.80 (5.67 to 7.93) | −0.04 (−0.44 to 0.36) | 6.83 (5.65 to 8.02) | <0.001 |
| Change in serum TNF receptor I (pg/ml), (95% CI) | −27.6 (−93.4 to 38.2) | 104.5 (−23.7 to 232.6) | 132.1 (−10.3 to 274.4) | 0.07 |
| Change in serum TNF receptor II (pg/ml), (95% CI) | 26867 (24181 to 29553) | 297 (15 to 581) | 26569 (23870 to 29268) | <0.001 |
CRP, C-reactive protein; TNF, tumour necrosis factor.