Top 10 upregulated mRNA in lung tissue from subjects with COPD compared with smokers without COPD
| Gene ID | Gene title | Gene symbol | Fold difference (COPD/normal smokers) | p Value | pFDR value | Function |
| 9507 | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | ADAMTS4 | 8.91 | 2.16E-04 | 4.02E-04 | Proteolytic activity |
| 7011 | Telomerase-associated protein 1 | TEP1 | 7.24 | 4.88E-13 | 5.06E-11 | Alternative splicing, nucleo-cytoplasmic transport |
| 10949 | Heterogeneous nuclear ribonucleoprotein A0 | HNRNPA0 | 6.86 | 8.02E-22 | 5.24E-18 | mRNA processing, transport and metabolism |
| 2304 | Forkhead box E1 (thyroid transcription factor 2) | FOXE1 | 6.30 | 4.02E-05 | 1.01E-04 | Transcription factor, thyroid gland organogenesis |
| 4001 | Lamin B1 | LMNB1 | 6.05 | 8.44E-12 | 4.52E-10 | Nuclear stability, chromatin structure |
| 117245 | HRAS-like suppressor family, member 5 | HRASLS5 | 5.26 | 1.59E-17 | 1.44E-14 | Transferase, catalytic activity |
| 3569 | Interleukin 6 (interferon, beta 2) | IL6 | 5.18 | 1.50E-03 | 2.01E-03 | Inflammation, B cell differentiation |
| 6280 | S100 calcium binding protein A9 | S100A9 | 5.14 | 8.17E-07 | 4.14E-06 | Cell cycle progression, differentiation, immune system |
| 6696 | Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T lymphocyte activation 1) | SPP1 | 5.10 | 6.58E-05 | 1.51E-04 | Metabolic process, cellular organisation, binding |
| 27097 | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kDa | TAF5L | 4.95 | 2.05E-12 | 1.51E-10 | Histone acetylase |
COPD, chronic obstructive pulmonary disease; pFDR, positive false discovery rate.