Table 3

Summary of the performed meta-analyses (random-effects model)

Meta-analysisHR/OR (95% CI)I2 (%)Degree of heterogeneity
Overall analysis (recurrence)
 Recurrence (overall)OR 4.82 (2.45 to 9.51)85High
 Recurrence (local)OR 2.42 (1.48 to 3.95)0Low
 Recurrence (loco-regional)OR 2.13 (1.32 to 3.45)0Low
 Recurrence (pleural)OR 9.89 (5.95 to 16.44)33Moderate
 Recurrence (distant)OR 3.18 (1.56 to 6.46)86High
Overall analysis (survival)
 Total follow-up (all studies)HR 2.08 (1.71 to 2.52)71Moderate
 Total follow-up (stage I)HR 4.20 (2.65 to 6.65)55Moderate
Subgroup analysis (overall recurrence)
 Study size (>350 patients)OR 4.40 (1.52 to 12.73)88High
 Positive PLC % (<5%)OR 10.01 (5.09 to 19.69)11Low
 Study score (high quality)OR 5.07 (1.70 to 15.19)82High
Subgroup analysis (survival)
 Study score (high quality)HR 1.74 (1.37 to 2.23)71Moderate
  • Please note, the degree of heterogeneity was graded as low (I2 <25%), moderate (I2 =25–75%) or high (I2 >75%).