Diagnosis and treatment of recognised comorbidities in severe asthma
| Comorbid condition | Test | Treatment |
| Gastro-oesophageal reflux | 3 months empirical therapy trial with proton pump inhibitors or oesophageal pH testing | Lifestyle modifications |
| Proton pump inhibitors | ||
| Surgery | ||
| Obesity with or without obstructive sleep apnoea syndrome | Polysomnography | Weight control |
| Positive airway pressure | ||
| Oral appliances | ||
| Surgery | ||
| Sinus disease | CT scan | Nasal irrigation with saline |
| Nasendocopy | Corticosteroid spray | |
| Corticosteroid drops | ||
| Surgery | ||
| Depression/anxiety | Evaluation by mental health professional | Medical treatment or psychotherapy by mental health professional |