Nutrition, inflammation and infection data
| Initial assessment (n=36) | Year 1 assessment (n=42) | Year 2 assessment (n=42) | Year 3 assessment (n=42) | |
| Height (cm) | 57 (44 to 73) | 78 (67 to 85) | 88 (76 to 102) | 98 (85 to 107) |
| Height z-score | −0.9 (−7.4 to 5.0) | 0.1 (−3.7 to 2.3) | −0.1 (−3.1 to 3.9) | −0.3 (−2.7 to 2.7) |
| Weight (kg) | 4.8 (2.7 to 10.0) | 10.7 (7.2 to 14.7) | 12.9 (9.4 to 17.5) | 15.0 (10.8 to 18.8) |
| Weight z-score | −1.7 (−5.6 to 2.3) | 0.0 (−3.2 to 2.4) | 0.1 (−2.6 to 2.2) | −0.1 (−2.8 to 1.6) |
| BMI | 14.7 (10.1 to 18.8) | 17.8 (1.6 to 21.0) | 16.3 (13.2 to 18.9) | 15.7 (13.1 to 17.7) |
| BMI z-score | −1.5 (−5.7 to 2.0) | 0.5 (−3.9 to 2.4) | −0.2 (−2.9 to 1.6) | −0.1 (−2.5 to 1.2) |
| Neutrophils (% of total cell) | 25. 2 (4.0 to 76.7) | 22.0 (4.3 to 80.3) | 17.0 (2.0 to 83.3) | 27.3 (2.67 to 87.0) |
| Neutrophils (×103/ml) | 70.6 (2.89 to 394) | 78.0 (10.7 to 1510) | 44.4 (4.19 to 2210) | 124.8 (4.89 to 1460) |
| No. (%) in whom IL-1β was detected | 17 (47.2) | 23 (54.8) | 19 (45.2) | 26 (61.9) |
| IL-1β (pg/ml) | 39.7 (20.5 to 397) | 55.3 (28.0 to 2710) | 50.1 (20.1 to 151) | 44.2 (21.7 to 569) |
| No. (%) in whom IL-6 was detected | 18 (50.0) | 22 (52.4) | 23 (54.8) | 25 (59.5) |
| IL-6 (pg/ml) | 50.0 (20.0 to 88.1) | 46.9 (25.1 to 192) | 46.4 (11.8 to 5000) | 79.6 (19.2 to 1660) |
| No. (%) in whom IL-8 was detected | 30 (83.3) | 34 (81.0) | 35 (83.3) | 36 (90) |
| IL-8 (pg/ml) | 400 (120 to 2845) | 490 (120 to 5430) | 755 (110 to 66000) | 1310 (150 to 22500) |
| No. (%) in whom TNFα was detected | 0 (0) | 0 (0) | 0 (0) | 2 (4.8) |
| TNFα (pg/ml) | Not detected | Not detected | Not detected | 47.7 (38.6 to 56.7) |
| No. (%) in whom NE was detected | 13 (36.1) | 8 (19.0) | 9 (21.4) | 13 (32.5) |
| NE (ng/ml) | 1330 (300 to 11725) | 2240 (1090 to 10080) | 3115 (250 to 18950) | 1935 (240 to 10270) |
| No. (%) in whom MPO was detected | 8 (22.2) | 16 (38.1) | 20 (47.6) | 21 (50.0) |
| MPO (ng/ml) | 420 (48.7 to 2405) | 118 (9.1 to 1381) | 350.5 (5.4 to 2970) | 861 (7.0 to 7536) |
| No. (%) with any infection (at least 104 CFU/ml) | 18 (50) | 11 (26.2) | 12 (28.6) | 16 (38.1) |
| No. (%) in whom S aureus was detected | 9 (25.0) | 3 (7.1) | 6 (14.3) | 7 (17.5) |
| No. (%) in whom P aeruginosa was detected | 3 (8.3) | 4 (9.5) | 4 (9.5) | 4 (10.0) |
| No. (%) on S aureus prophylaxis | 17 (42.5) | 31 (73.8) | 26 (61.9) | 24 (57.1) |
Data are presented as the median (range) or number (%). Inflammation data are reported from subjects in whom pulmonary inflammation was detected in broncho-alveolar lavage.
BAL, bronchoalveolar lavage; BMI, body mass index; CFU, colony-forming units; IL, interleukin; MPO, myeloperoxidase; NE, neutrophil elastase; TNF, tumour necrosis factor.