Results of invasive tests in CT or PET-CT negative patients
| N-final | ||||
| N0–1 | N2–3 | Nx | Total | |
| (a) Yield of mediastinoscopy | ||||
| CT N2–3 | ||||
| Mediastinoscopy* | ||||
| N0–1† | 51 | 24 | 3 | 78 |
| N2–3 | – | 15 | 0 | 15 |
| 93 | ||||
| PET-CT N2–3 | ||||
| Mediastinoscopy | ||||
| N0–1‡ | 9 | 10 | 2 | 21 |
| N2–3 | – | 6 | 0 | 6 |
| 27 | ||||
| (b) Yield of EUS-FNA | ||||
| CT N2–3 | ||||
| EUS-FNA§ | ||||
| N0–1¶ | 20 | 5 | 0 | 25 |
| N2–3 | – | 21 | 0 | 21 |
| 46 | ||||
| PET-CT N2–3 | ||||
| EUS-FNA | ||||
| N0–1** | 6 | 0 | 0 | 6 |
| N2–3 | – | 10 | 0 | 10 |
| 16 | ||||
↵* Overall NPV of mediastinoscopy was 76% (107/141, 95% CI 68% to 82%).
↵† NPV of mediastinoscopy when CT is positive: 68% (57% to 77%).
↵‡ NPV of mediastinoscopy when PET-CT is positive: 47% (27% to 68%).
↵§ Overall NPV of EUS-FNA is 85% (35/41) (72% to 93%).
↵¶ NPV of EUS-FNA when CT is positive: 80% (61% to 91%).
↵** NPV of EUS-FNA when PET-CT is positive: 100% (61% to 100%).
EUS, endoscopic ultrasound; FNA, fine needle aspiration; NPV, negative predictive value; PET, positron emission tomography.