Table 2

Spearman's correlation analysis between matrix metalloproteinases (MMPs), spirometry, CT measures of disease and cytokines and neutrophils in subjects with COPD

	MMP-1	MMP-2	MMP-3	MMP-7	MMP-8	MMP-9	MMP-10	MMP-12	MMP-13	EMMPRIN
Cytokines and neutrophils
IL-1β	0.26	−0.20	−0.44*	0.08	0.30	0.21	−0.21	−0.00	0.18	0.22
IL-6	0.51*	−0.18	0.28	0.55**	0.69***	0.55**	0.21	0.52**	−0.22	0.54**
IL-8	0.44*	−0.26	0.06	0.53**	0.90***	0.78***	0.16	0.56**	−0.01	0.46*
GM-CSF	−0.02	−0.16	−0.25	0.15	0.41*	0.41*	0.13	0.20	−0.31	0.68***
Neutrophils	−0.12	0.07	0.44	0.40	0.41	0.28	0.25	0.29	−0.26	0.36
Spirometry
FEV1%	−0.35	0.28	−0.34	−0.35	−0.60**	−0.59**	−0.19	−0.51*	0.02	−0.20
FEF25%–75%	−0.47*	0.39	−0.03	−0.18	−0.61**	−0.58**	−0.11	−0.44*	0.22	−0.22
CT parameters
Emphysema % (LAA%)	−0.03	−0.05	0.49*	0.52**	0.35	0.33	0.52*	0.09	−0.24	0.14
Small airways disease (E/I MLD)	0.16	−0.14	0.52*	0.52*	0.60*	0.56*	0.55*	0.50*	−0.03	0.32
Bronchial wall area (Pi10)	0.12	0.08	0.04	0.11	0.23	0.21	0.13	0.17	0.20	0.15

Spearman's r values given.
N=24, apart from associations with E/I MLD (n=16).
*p<0.05, **p<0.01, ***p<0.001.
IL, interleukin.