Group mean change from hospital admission for quality of life (day 7 and discharge), exercise tolerance and sputum microbiology (day 7)
| Outcome | Change from admission to day 7 | Change from admission to discharge | ||||
|---|---|---|---|---|---|---|
| Hypertonic saline (n=67) Mean±SD | Control (n=65) Mean±SD | Between-group difference Mean (CI) | Hypertonic saline (n=67) Mean±SD | Control (n=65) Mean±SD | Between-group difference Mean (CI) | |
| SF36 (0–100) | ||||||
| Physical | 11±18 | 7±13 | 4 (−1 to 9) | 13±19 | 9±19 | 4 (−2 to 10) |
| General health | 5±12 | 5±13 | 0 (−4 to 4) | 7±11 | 8±16 | −1 (−6 to 4) |
| Vitality | 7±15 | 6±12 | 2 (−3 to 6) | 11±20 | 13±15 | −1 (−7 to 4) |
| CFQ (0–100) | ||||||
| Physical | 11±16 | 9±14 | 2 (−4 to 7) | 16±19 | 14±17 | 3 (−4 to 9) |
| Burden | 0±14 | 0±14 | −1 (−6 to 4) | 1±15 | −1±20 | 1 (−4 to 7) |
| Health | 12±19 | 14±17 | −2 (−8 to 4) | 20±21 | 18±20 | 2 (−5 to 10) |
| Respiratory | 13±19 | 12±16 | 1 (−5 to 7) | 19±21 | 21±18 | −2 (−8 to 5) |
| MST-25 (0–100) | 166±138 | 120±210 | 46 (−19 to 110) | |||
| Bacterial density (log10CFU/g) | ||||||
| Pseudomonas aeruginosa | −0.8±2.2 | −1.1±2.2 | 0.2 (−0.6 to 1.1) | |||
| Staphylococcus aureus | −0.4±1.4 | −0.8±1.6 | 0.4 (−0.8 to 1.6) | |||
CFQ, Cystic Fibrosis Questionnaire; CFU, colony forming units; CFU/g, colony forming units per gram of sputum; MST-25, Modified Shuttle Test 25; SF36, Medical Outcomes Survey Short Form 36.